人核迁移蛋白C在鼻咽癌组织中的表达及临床意义  

Expression and Clinical significance of human nuclear distribution C in nasopharyngeal carcinoma

作　　者：陈彦球 杨燕[2] 林志斌[3] 彭华[3] 卢汉桂[3] 

机构地区：[1]广州市妇女儿童医疗中心,广州510632 [2]中山大学公共卫生学院 [3]中山大学第一附属医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2011年第2期71-73,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：广东省自然科学基金博士启动资助项目(No:06300645);教育部博士点基金新教师资助项目(No:20070558275)

摘　　要：目的:明确鼻咽癌(NPC)组织中人核迁移蛋白C(hNudC)的表达及其临床意义。方法:应用免疫组织化学方法和Western blot方法检测80例NPC和30例鼻咽黏膜慢性炎组织中hNudC的表达情况,并应用条带密度分析软件半定量分析Western blot条带密度。结果:在NPC中,hNudC阳性表达率为83.75%(67/80),明显高于鼻咽部黏膜慢性炎症组织23.33%(7/30)(P<0.05),hNudC蛋白的阳性表达率随着NPC临床分期的进展而增加(P<0.05)。结论:hNudC基因表达与NPC细胞恶性增殖密切相关,检测其表达对研究NPC的发生、发展具有一定临床意义。Objective： To investigate the expression and clinical significance of human nuclear distribution（hNudC） in nasopharygeal carcinoma（NPC）.Method：Immunohistochemical and western blot method were used to determine the expression of human nuclear distribution C in 80 cases of NPC and 30 cases of chronic inflammation of nasopharyngeal mucosa.The amounts of positive cells were analyzed.The relationship between the gene expression and clinic pathological features was analyzed too.Result：The positive expression rate of human nuclear distribution C in NPC was 83.75 %,which was higher than that in chronic inflammation of nasopharyngeal mucosa 23.33%（P〈0.05）.The expression of human nuclear distribution C was positively correlated with the clinic pathological stages in NPC（P〈0.05）,and positive expression rate of hNudC protein was increased with the progress of NPC clinical stage（P〈0.05）.Conclusion：Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia.This protein is important indicators to predict the progression of patients.

关 键 词：鼻咽肿瘤 人核迁移蛋白C 

分 类 号：R739.6[医药卫生—肿瘤]