拉坦噻吗滴眼液治疗青光眼临床疗效观察  

Clincal observation of latanoprost and timolol maleate eye drops in treatment of glaucoma

作　　者：刘梅[1] 赖铭莹[1] 成洪波[1] 黄丽娜[1] 邓丽红[1] 贺温玲[1] 

机构地区：[1]暨南大学附属深圳眼科医院青光眼科,中国广东省深圳市518034

出　　处：《国际眼科杂志》2011年第2期358-359,共2页International Eye Science

摘　　要：目的:评价拉坦噻吗滴眼液(适利加)降眼压治疗的有效性和安全性。方法:选取30例52眼原发性开角型/闭角型青光眼患者单用拉坦噻吗滴眼液,每晚1次,随访16wk,观察眼压、视野、平均视神经纤维层厚度及不良反应。结果:拉坦噻吗滴眼液能显著降低眼压(P=0.000),16wk后降眼压幅度的95%可信区间为10.31～13.92mmHg,但对视野及平均视神经纤维层厚度无改善(P>0.05),不良反应主要为眼睛轻度充血。结论:拉坦噻吗滴眼液能显著降低原发性开角型/闭角型青光眼患者的眼压,而且用药安全,依从性好。但短期随访并未发现其对视野及平均视神经纤维层厚度有改善。AIM：To evaluate the efficacy and safty of latanoprost and timolol maleate eye drops reducing IOP.METHODS：Fifty-two eyes of 30 primary glaucoma patients were dosed with latanoprost and timolol maleate eye drops as a single therapy once daily.The observed signs included IOP,field of vision,mRNFL and complications.The follow-up duration was 16 weeks.RESULTS：Latanoprost and timolol maleate eye drops reduced IOP significantly（P=0.000）,but didn＇t have effects to field of vision and mRNFL.After 16 weeks,95% confidence interval of IOP reductions ranged from 10.31 to 13.92mmHg.The most complications was conjunctival congestion.CONCLUSION：Latanoprost and timolol maleate eye drops reduced IOP significantly in primary glaucoma patients and was safe and well tolerated.But the field of vision and mRNFL are not ameliorated within short-term follow-up.

关 键 词：拉坦噻吗滴眼液 青光眼 

分 类 号：R775[医药卫生—眼科]