乳腺原发性黏液性囊腺癌临床病理分析和文献复习  

Clinicalpathologic analysis of primary mucinous cystadenocarcinoma of the breast and review of literatures

作　　者：杨雯娟[1] 魏兵[1] 倪韵碧[1] 刘裔莎[1] 尹丽娟[1] 步宏[1] 

机构地区：[1]四川大学华西医院病理科,成都610041

出　　处：《临床与实验病理学杂志》2011年第1期30-33,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨乳腺原发性黏液性囊腺癌(mucinous cystadenocarcinoma,MCA)的临床病理特征及鉴别诊断。方法分析1例MCA的组织病理学、免疫表型资料并复习文献。结果乳腺肿物切面呈囊实性。镜下见大小不等、分布不均的囊性区,囊壁衬覆富含黏液的肿瘤细胞,或呈单层柱状、或复层化增生或形成乳头状结构。肿瘤细胞胞质内黏液呈PAS、AB染色阳性。肿瘤细胞CK7阳性,CK20阴性,ER、PR、HER2均阴性。囊壁肿瘤细胞外侧肌上皮细胞呈p63、SMA阴性。结论 (1)MCA是主要发生于绝经后妇女的罕见肿瘤,预后较好。(2)与卵巢和(或)胰腺黏液性囊腺癌类似,诊断原发肿瘤需先排除转移可能。Purpose To study the clinicalpathologic features and differential diagnosis of primary mucinous cystadenocarcinoma of the breast（MCA）.Methods Pathological characteristics and immunophenotype of one case of MCA were analyzed.Literatures were reviewed.Results Grossly,the lession was cystic-solid.Microscopically,the tumor was characterized by variably sized and unevenly distributed cystic areas lined by mucus-rich tumor cells with simple columnar,stratificational and papillary formation.Mucus in the cytoplasm of tumor cells was positive for PAS、AB in special staining.The tumor cells were positive for CK7,negative for CK20,ER,PR,and HER2.Peripheral myoepithelial cells were negative for p63 and SMA.Conclusions（1）MCA is a rare primary breast cancer prone to affecting postmenopausal women with better prognosis.（2）The diagnosis of the primary tumor can not be rendered until the metastatic is ruled out,which is the same case in ovarian and（or）pancreatic mucinous cystadenocarcinoma.

关 键 词：乳腺肿瘤 黏液癌 黏液性囊腺癌 转移 

分 类 号：R737.9[医药卫生—肿瘤]