乳腺导管内癌和浸润性导管癌中骨桥蛋白的表达及意义  

Expression of osteopontin in breast intraductal carcinoma and infiltrating ductal carcinoma and its clinical significance

作　　者：李曦洲[1] 隋金珂[1] 谢轶群[1] 施俊义[1] 

机构地区：[1]第二军医大学长海医院甲乳外科,上海200433

出　　处：《第二军医大学学报》2011年第1期49-52,共4页Academic Journal of Second Military Medical University

摘　　要：目的探讨正常乳腺组织、乳腺导管内癌和浸润性导管癌中骨桥蛋白(osteopontin,OPN)的表达及临床意义。方法应用免疫组化S-P法测定OPN在正常乳腺组织、乳腺导管内癌和浸润性导管癌中的表达,采用SPSS 13.0软件进行统计学分析。结果正常乳腺组织、乳腺导管内癌、浸润性导管癌OPN的阳性表达率分别为0%(0/20)、20.0%(5/25)、43.1%(25/58),组间差异有统计学意义(P<0.05)。有否家族史、不同年龄、不同原发肿瘤大小的浸润性导管癌患者间OPN的表达差异无统计学意义,但不同组织学分级、不同临床TNM分期、腋窝淋巴结转移与否患者间OPN的表达差异有统计学意义(P<0.05)。结论 OPN可能参与了乳腺癌的发生、发展和转移,有利于乳腺癌的预后判断。Objective To investigate the expression of osteopontin（OPN） in normal breast epithelium,intraductal carcinoma and infiltrating ductal carcinoma and its clinical significance.Methods The expression of OPN was examined by S-P immunohistochemistry in all specimens,and the results were statistically analyzed.Results The positive rates of OPN in normal breast epithelium,intraductal carcinoma and infiltrating ductal carcinoma specimens were 0%（0 /20）,20.0%（5 /25） and 43.1%（25 /58）,respectively,with significant differences found between the latter two groups（P 0.05）.OPN expression in breast infiltrating ductal carcinoma was not correlated with the family history,the sizes of primary tumor or patient ages,and it was correlated with histological types,clinical TNM stages and axillary lymphatic metastasis（P 0.05）.Conclusion OPN may participate in the development,progression,metastasis of breast cancer,and it may be used for predicting the prognosis of breast cancer.

关 键 词：乳腺肿瘤 非浸润性导管内癌 浸润性导管癌 免疫组织化学 骨桥蛋白质 

分 类 号：R737.9[医药卫生—肿瘤]