猪传染性胃肠炎病毒基因工程疫苗研究进展  

Research Progress of Transmissible Gastroenteritis Virus (TGEV) Genetic Engineering Vaccine

作　　者：杨恒[1] 夏雪山[1] 李盛陶[1] 陈伟[1] 

机构地区：[1]昆明理工大学生命科学与技术学院,昆明650224

出　　处：《生物技术通报》2011年第2期28-32,共5页Biotechnology Bulletin

基　　金：云南省自然科学基金项目(2010ZC058)

摘　　要：猪传染性胃肠炎是由猪传染性胃肠炎病毒(TGEV)引起猪的一种高度接触性肠道疾病,可导致仔猪发生严重的呕吐、腹泻与脱水,死亡率可达100%。口服疫苗是TGEV基因工程疫苗研究的主要方向,目前已在腺病毒、细菌、转基因植物及DNA疫苗中对TGEV的S基因进行了表达,并对其口服免疫后的免疫原性进行研究。现针对TGEV基因工程疫苗近年来研究的概况进行综述,分析其优点与不足,并对其未来的发展进行展望。Porcine transmissible gastroenteritis is a highly contagious,enteric disease of swine caused by transmissible gastroenteritis virus（TGEV）.The disease is especially severe in baby pigs less than two weeks old,characterized by vomiting,severe diarrhea,and nearly 100% mortality.New developments of TGEV genetic engineering vaccine have focused on production and delivery of the S protein through oral immunization.At present,several systems such as adenovirus,bacteria,transgenic plant,and DNA vaccine have been used to express the TGEV S proteins.After oral immunization,the immunogenicity of these vaccines has been studied.The research progress of TGEV genetic engineering vaccine were reviewed in this article,its advantage,disadvantage and further development were also prospected.

关 键 词：猪传染性胃肠炎病毒 基因工程疫苗 口服免疫 

分 类 号：S858.28[农业科学—临床兽医学]