结缔组织生长因子与肝脏纤维化  

The relationship between connective tissue growth factor and hepatic fibrosis

作　　者：谢永鹏[1] 臧秀贤[1] 吴扬[1] 李迎今[1] 张楠[1] 

机构地区：[1]吉林大学第一医院急诊科,长春130021

出　　处：《临床肝胆病杂志》2011年第1期103-106,共4页Journal of Clinical Hepatology

摘　　要：结缔组织生长因子(CTGF)具有促成纤维细胞增殖、胶原及细胞外基质合成等作用,是一种促器官纤维化的重要细胞因子。CTGF与肝纤维化的发生密切相关,在人肝纤维化、肝硬化及实验性肝纤维化模型中CTGF的表达显著增加,而抑制肝细胞CTGF的表达可显著减少胶原等细胞外基质的表达,有效的阻抑肝纤维化的进程。有关CTGF的进一步研究将对于揭示肝纤维化及肝硬化发病和治疗机理以及临床诊治等具有重要的意义。本文对CTGF的功能及其在肝纤维化形成、诊断和治疗中作用进行了综述和讨论。The connective tissue growth factor（CTGF） can enhance the proliferation of fibroblasts and promote the extra cellular matrix synthesis.It is an important cytokine that can promote organ fibrosis.There is a strong correlation between the CTGF and hepatic fibrosis.The CTGF expression of human hepatic fibrosis,cirrhosis and experimental hepatic fibrosis model is significantly rising.The inhibition of CTGF expression can reduce the extra cellular matrix synthesis,resulting in the inhibition of hepatic fibrosis.The further study of CTGF is important for the pathogenesis,therapeutic mechanism and the clinical treatment of hepatic fibrosis and cirrhosis.In the review,the function of CTGF and its state on the pathogenic process,diagnosis and treatment of hepatic fibrosis were summarized and discussed.

关 键 词：胞间信号肽类和蛋白质类 即早蛋白质类 肝硬化 

分 类 号：R575.2[医药卫生—消化系统]