人工寒潮对颈动脉粥样硬化性大鼠血压的影响  

Effect of artificial cold exposure on the blood pressure of rats with carotid atherosclerosis

作　　者：朱秋艳 唐震宇[2] 徐丽君[2] 曾瀛[2] 邓丽影[2] 丁卫江[2] 黄卫[2] 

机构地区：[1]江西省宜春市人民医院神经内科,336000 [2]南昌大学第二附属医院神经内科,南昌330006

出　　处：《中华神经医学杂志》2011年第1期46-49,共4页Chinese Journal of Neuromedicine

基　　金：“十一五”国家科技支撑计划项目课题资助（2008BA168B03）

摘　　要：目的 探讨人工寒潮对颈动脉粥样硬化性大鼠血压的影响以及尼莫地平的干预作用.方法 将SD大鼠按随机数字表法分为正常组、假手术组和颈动脉粥样硬化组,其中颈动脉粥样硬化组再分为非寒潮组、寒潮组和干预组3个亚组,除非寒潮组外其他各组均经历人工寒潮3d,寒潮组并给予等剂量生理盐水灌胃3 d,干预组并给予尼莫地平干预,分别测量各组经历寒潮前后的血压.结果 （1）寒潮前假手术组及颈动脉粥样硬化组血压明显高于正常组,比较差异有统计学意义（P＜0.05）.（2）寒潮后正常组、假手术组及寒潮组的血压较寒潮前明显增高,干预组血压较寒潮前明显下降,比较差异均有统计学意义（P＜0.05）.（3）正常组、假手术组及寒潮组之间寒潮前后血压的差值比较无统计学差异.（4）与寒潮组相比,干预组的血压差值明显降低,比较差异有统计学意义（P＜0.05）.结论 人工寒潮可以使正常大鼠及颈动脉粥样硬化性大鼠血压升高,尼莫地平可以预防寒潮导致的血压升高.Objective To study the effect of artificial cold exposure （ACE） on the level of blood pressure in carotid atherosclerotic rats, and the prophylactic effect of nimodipine on it. Methods One hundred and thirty SD rats were randomly divided into normal group （n=10）, sham-operated group （n=10）, and carotid atherosclerotic （CAS） group （n=110）. High-fat diet was given to the sham-operated group and CAS group; normal diet was given to the control group. Then, 105 alive rats in the CAS group were further sub-divided into non-ACE group （n=40）, ACE group （n=38） and nimodipine treatment group （n=37）. All the groups were subjected to ACE for 3 d except non-ACE group, and kept at 22 °C throughout the experiment. During the ACE, an intragastric administration of nimodipine was given to the nimodipine treatment group. The changes of the blood pressure before and after ACE were analyzed and compared. Results The level of pre-ACE blood pressure in the sham-operated group and CAS group was significantly higher than that in the normal group （P〈0.05）. The level of post-ACE blood pressure was significantly increased in the normal group, sham-operated group and ACE group, and significantly decreased in the nimodipine treatment group as compared with the level of pre-ACE one in these groups （P〈0.05）. No significant differences were noted between the levels of pre-ACE and post-ACE blood pressure in the normal group, sham-operated group and ACE group （P〉0.05）. The level of post-ACE blood pressure in rats treated with nimodipine was obviously decreased as compared with that in the ACE group （P〈0.05）. Conclusion ACE could increase the level of blood pressure in carotid atherosclerotic rats and this effect might be lessoned by the administration of nimodipine.

关 键 词：人工寒潮 颈动脉粥样硬化 血压 尼莫地平 

分 类 号：R743.3[医药卫生—神经病学与精神病学]