长期海洛因成瘾者前额叶功能连接的静息态fMRI研究  

Functional connectivity of prefrontal cortex in chronic heroin addicts： a resting-state functional MRI study

作　　者：齐印宝 傅先明[1] 钱若兵[1] 魏祥品[1] 牛朝诗[1] 王昌新[2] 曾飞雁[2] 汪业汉[1] 

机构地区：[1]安徽医科大学附属省立医院神经外科,合肥230001 [2]安徽医科大学附属省立医院磁共振室,合肥230001

出　　处：《中华神经医学杂志》2011年第1期76-79,共4页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金（30973084）;安徽省自然科学基金（070413264X）;安徽省卫生厅医学科研课题（098137）

摘　　要：目的 利用静息态fMRI探讨长期海洛因成瘾者前额叶功能连接的变化情况.方法 13例长期海洛因成瘾者和14例正常者接受静息态fMRI检查,对数据进行相关的预处理后,以前额叶为种子点与全脑每个体素进行相关分析,比较海洛因成瘾组与正常对照组前额叶功能连接的变化情况.结果 以左侧前额叶为种子点进行功能连接分析,海洛因成瘾组左侧前额叶与左侧海马、右侧前扣带回、左侧额中回、右侧额中回、右侧楔前叶功能连接明显低于正常对照组：以右侧前额叶为种子点进行功能连接分析,海洛因成瘾组右侧前额叶与左侧眶额叶、左侧额中回功能连接明显低于正常对照组.结论 长期海洛因成瘾者前额叶与相关脑区的功能连接减弱,前额叶可能参与了海洛因成瘾的维持与戒断后复吸.Objective To explore the changes of functional connectivity of the prefrontal cortex in chronic heroin addicts under resting-state functional MRI （fMRI）. Methods Resting fMRI examination was performed on 13 chronic heroin addicts and 14 healthy volunteers. After pre-processing the resting-state fMRI data, the prefrontal cortex was selected as the seed region, with which a whole-brain voxel temporal correlation in Iow frequency fMRI fluctuations was analyzed and the changes of functional connectivity of the prefrontal lobe in both chronic heroin addicts and healthy volunteers were calculated with SPM5 software. Results Compared with that in the control group, the functional connectivity between the left prefrontal cortex and the left hippocampus, right anterior cingulate, left middle frontal gyrus, right middle frontal gyrus, right precuneus in the heroin addiction group was significantly decreased. The functional connectivity between the right prefrontal cortex and the left orbital frontal cortex, left middle frontal gyrus in thc heroin addiction group was also significantly decreased as compared with that in the control group. Conclusion Functional connectivity of prefrontal cortex in chronic heroin addicts decreases, indicating that the prefrontal cortex may be involved in the maintenance of heroin addiction and relapse after withdrawal.

关 键 词：海洛因成瘾 前额叶 静息态fMRI 功能连接 

分 类 号：R749.64[医药卫生—神经病学与精神病学]