18F—FDG PET／CT检测神经系统副肿瘤综合征疑似患者恶性肿瘤的应用价值  

Value of 2-18F-2-deoxy-β-D-glucose PET/CT in tumor detection of patients suspected as having paraneoplastic syndromes

作　　者：关志伟[1] 徐白萱[1] 王瑞民[1] 尹大一[1] 田嘉禾[1] 

机构地区：[1]解放军总医院核医学科,北京100853

出　　处：《中华神经医学杂志》2011年第1期88-90,共3页Chinese Journal of Neuromedicine

摘　　要：目的 评价2-18F-2-脱氧-β-D-葡萄糖（18F-FDG）PET/CT在疑似神经系统副肿瘤综合征（PNS）患者中检测恶性肿瘤的应用价值.方法 回顾性分析解放军总医院核医学科自2007年6月至2009年12月行18F-FDG PET/CT检查的PNS疑似患者54例的临床资料,结合病理结果分析18F-FDGPET/CT检出恶性肿瘤的阳性率、阳性预测值以及患者的恶性肿瘤标记物和病程对检出率的影响.结果 18F-FDG PET/CT检查阳性17例（31.5%）,病理结果证实恶性13例,良性4例,18F-FDG PET/CT的阳性预测值为76.5%;恶性肿瘤检出组和未检出组的病程差异无统计学意义（P＞0.05）;肿瘤标记物阳性患者恶性肿瘤的检出率明显高于肿瘤标记物正常组,差异有统计学意义（P＜0.05）.结论 18F-FDG PET/CT提高了神经系统PNS疑似患者恶性肿瘤的检出率,肿瘤标记物阳性患者的恶性肿瘤的检出率更高.Objective To determine the value of 2-18F-2-deoxy-β-D-glucose （18F-FDG）PET/CT in malignancy tumor detection of patients suspected as having paraneoplastic syndrome （PNS）.Methods The clinical data of 54 patients suspected as having PNS, underwent PET/CT study in our hospital fiom June 2007 to December 2009, were retrospectively analyzed. The efficacy of 18F-FDG PET/CT on positive detection rate, positive predictive value of malignant tumors and on the detection of malignant tumor markers were analyzed with the results of pathological findings and clinical data;whether the course of disease could affect these detection was also analyzed. Results Positive results of 18F-FDG PET/CT were noted in 17 patients （31.5%）, and 13 of them were confirmed as malignant tumors with pathological results. The positive predictive value of 18F-FDG PET/CT was 76.5%. The durations of patients with malignancies were not different from those of patients without malignancies.PET/CT enjoyed a significantly higher efficacy rate in identifying malignant tumors in patients with elevated tumor markers than in patients with tumor markers in normal range （P〈0.05）. Conclusion 18F-FDG PET/CT improves the tumor detection rate in PNS suspects, especially in patients enjoying elevated tumor markers.

关 键 词：神经系统副肿瘤综合征 脑肿瘤 18F—FDG 

分 类 号：R739.4[医药卫生—肿瘤]