半枝莲黄酮对去卵巢大鼠记忆障碍的改善作用  

Improvement of Scutellaria Barbata flavonoid on impaired memory of ovariectomy rats

作　　者：郗玉玲[1] 刘敏华 张晓峰[1] 李敏 董永彩[1] 缪红[1] 商亚珍[1] 

机构地区：[1]河北省中药研究与开发重点实验室承德医学院中药研究所,河北承德067000 [2]承德市妇幼保健院

出　　处：《中国老年学杂志》2011年第2期242-245,共4页Chinese Journal of Gerontology

基　　金：河北省自然基金资助项目(No.C2009001007);河北省中医药管理局资助项目(No.05027)

摘　　要：目的研究半枝莲黄酮(SBF)对去卵巢大鼠记忆障碍的影响。方法 3月龄雌性大鼠摘除卵巢10个月,通过去卵巢大鼠的学习记忆能力、体重及输卵管/子宫、脾脏和胸腺指数和血清中雌二醇(E2)含量的检测,评价SBF对去卵巢大鼠记忆障碍的影响。结果与假手术组相比,摘除卵巢使大鼠的学习记忆能力降低、体重明显增加、输卵管/子宫、脾脏和胸腺指数皆显著降低、血清中雌二醇的含量下降。而SBF17.5、35和70mg/kg对去卵巢大鼠上述异常变化均有不同程度的改善。结论 SBF能够降低去卵巢大鼠的学习记忆障碍,改善免疫、内分泌异常变化,该作用可能有利于临床老年性痴呆病的治疗。Objective To detect the improvement of Scutellaria Barbata flavonoid（SBF） on impaired memory of ovariectomy rats.Methods Three month yeas old female rats was executed ovariectomy（OVX）.After 10 months,the learning and memory ability,body weight gain,oviduct/uterus,spleen and thymus index,serum estradiol were detected to evaluate the rat′s memory.Results Compared with sham group,learning and memory ability was decreased,body weight was increased,oviduct/uterus,spleen and thymus indexes,serum estradiol were decreased in OVX rats.17.5,35 and 70 mg/kg SBF could improve above indexes changes in various degree.Conclusions SBF can decrease the impaired memory of OVX rats,improve immune and endocrine abnormal changes,which is beneficial to the treatment of clinical senile dementia.

关 键 词：半枝莲黄酮 去卵巢大鼠 学习记忆 雌二醇 体重 输卵管/子宫指数 脾脏/胸腺指数 

分 类 号：R749.16[医药卫生—神经病学与精神病学]