帕金森大鼠纹状体区近红外光谱活体微创在位检测研究  

Minimally invasive monitoring of the striatum corpora of model rats with Parkinson's disease in vivo by near infrared spectroscopy

作　　者：孙涛[1] 钱志余[2] 王文宏[3] 戴峰[4] 

机构地区：[1]蚌埠医学院第一附属医院神经外科,蚌埠233004 [2]南京航空航天大学生物医学工程系,南京210016 [3]东南大学附属中大医院神经外科,南京210009 [4]东南大学附属南京市第二医院影像科,南京210003

出　　处：《神经解剖学杂志》2011年第1期24-28,共5页Chinese Journal of Neuroanatomy

基　　金：国家自然科学基金(30671997)

摘　　要：目的:探讨近红外光谱技术(NIRS)测量帕金森(PD)大鼠纹状体区局部优化散射系数(μs’)与局部脑血容量(rCBV)的特点。方法:利用光学探头微创测量40只模型组大鼠毁损侧与健侧纹状体区的μ’s与rCBV,并与20只假手术组和20只正常组大鼠双侧纹状体测量结果进行比较。结果:模型组毁损侧μs’与rCBV值分别与模型组健侧、假手术组和正常组双侧比较具有统计学差异(P<0.05);模型组健侧、假手术组和正常组双侧之间比较未见统计学差异。结论:通过近红外微创光学探头可以测量PD大鼠纹状体部的μs’与rCBV变化。Objective：To explore the features of reducing scattering coefficient（μs＇） and regional cerebral blood volume（rCBV） in striatum corpora of rats with Parkinson＇s disease（PD） by the near infrared spectroscopy（NIRS）.Methods：The impaired and uninjured sides of 40 PD rats＇ striatum corpora were measured mini-invasively by optic fiber probe revealing μs＇ and CBV,then the data were compared with both sides of 20 rats in sham operated group and 20 rats in normal group.Results：The results of μs＇ and rCBV in impaired side of PD were different comparing with the uninjured side,both sides,sham operated and normal groups,respectively;there was no difference comparing with the uninjured side of PD group and both sides of sham operated and normal groups.Conclusion：The changes of μs＇ and rCBV in rat with PD can be detected in vivo by means of NIRS technique.

关 键 词：近红外光谱 帕金森病 优化散射系数 脑血容量 大鼠 

分 类 号：R742.5[医药卫生—神经病学与精神病学]