趋化因子CCL15在肝细胞肝癌组织中的表达及其临床意义  

Expression of CCL15 in Hepatocellular Carcinoma and Its Clinical Significance

作　　者：李悦国[1] 张宁[2] 

机构地区：[1]天津市肿瘤防治重点实验室,天津医科大学附属肿瘤医院检验科,天津市300060 [2]天津市肿瘤研究所中心实验室

出　　处：《中国肿瘤临床》2011年第2期87-88,93,共3页Chinese Journal of Clinical Oncology

摘　　要：目的:研究趋化因子CCL15在肝细胞肝癌(HCC)组织中的表达及其临床意义,并对CCL15与肝癌的恶性行为之间关系进行研究。方法:80例HCC、80例癌旁组织和50例正常肝组织标本常规制作石蜡包埋切片,CCL15染色为SP免疫组化法。结果:HCC组织中的CCL15表达阳性率及其评分明显高于癌旁组织和正常肝组织(P<0.05),在癌旁组织和正常肝组织之间没有差异;CCL15的蛋白表达与患者的性别、年龄、肝硬化、病理学分级、术前AFP浓度无明显关系(P>0.05),而与肿瘤的大小、癌栓、有无包膜以及TNM分期等有显著关系。结论:CCL15的表达与HCC的一些恶性临床病理特征密切相关,提示CCL15可能是反映HCC发生发展、侵袭、转移的一个重要的生物学指标。Objective： To study the expression of CCL15 in hepatocellular carcinoma （HCC） and its clinicopathologic significance, and to study the relationship between expression levels of CCL15 and malignant behaviors of HCC. Methods： Immunohistochemistry （SP method） was used to detect expression of CCL 15 in paraffin-embedded sections from 80 cases of HCC, 80 samples of adjacent tissue and 50 samples of normal liver tissue. Results： The positive rates of CCL 15 were significantly higher in HCC than in adjacent tissue specimens and normal liver tissue （ P 〈 0.05 ）. No significant difference was found between adjacent tissue specimens and normal liver tissue （ P 〈 0.05）. The expression of CCL15 was significantly correlated with tumor size and tumor thrombi in the portal vein （ P〈 0.05 ）, but not with sex, age, liver cirrhosis or the level ofAFP （ P〉 0.05 ）. Conclusion： The expression of CCL15 was significantly correlated with malignant behaviors of HCC, thus CCL15 might be an important biological marker in the oncogenesis, progression. biolouical behavior and prognosis of HCC.

关 键 词：肝细胞肝癌 CCL15 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]