迟发型阿尔茨海默病的基因研究进展  

Genes Associated with Late-onset Alzheimer Disease

作　　者：吴林林[1] 白燕[1] 许秀峰[1] 

机构地区：[1]昆明医学院第一附属医院精神科,昆明650032

出　　处：《医学综述》2011年第2期192-194,共3页Medical Recapitulate

摘　　要：阿尔茨海默病(AD)是目前最常见的老年性疾病,是一种以记忆和认知方面逐渐退化为主的神经退行性变疾病。早发型AD多与遗传基因的改变相关,而迟发型AD多与易感基因、环境因素及感染等相关。目前发现与迟发型AD相关的较明确的易感基因只有载脂蛋白E,现对迟发型AD相关的易感基因和近期发现的可能与迟发型AD相关的基因予以综述。Alzheimer disease（AD）is the main type of senile dementia.It is a neurodegenerative disease characterized by the generally degenerated memory and cognition.Researches suggest that early-onset AD is mostly related with the changes or mutations of some genes,whereas late-onset AD is mostly correlated with susceptibility genes,environmental factors,life-style,and infection.Apolipoprotein E4 is the single susceptibility gene that is more clearly associated with late-onset AD.This paper reviews the susceptibility genes related with late-onset AD.

关 键 词：迟发型阿尔茨海默病 载脂蛋白E 原钙黏蛋白 神经前体细胞发育下调表达因子9 

分 类 号：R749.16[医药卫生—神经病学与精神病学]