VEGF-C与胃癌淋巴结转移的相关性研究进展  

Progress of Correlation between VEGF-C and Lymph Node Metastasis in Gastric Cancer

作　　者：郭浩[1] 冯义朝[1] 

机构地区：[1]延安大学附属医院消化内科,陕西延安716000

出　　处：《医学综述》2011年第2期210-213,共4页Medical Recapitulate

摘　　要：淋巴管是肿瘤转移的一个重要途径,随着越来越多淋巴管标志物的发现,血管内皮生长因子C(VEGF-C)及受体血管内皮生长因子受体3在肿瘤淋巴管生成、肿瘤经淋巴结转移过程中的作用机制取得了较大进展。VEGF-C的表达与胃癌淋巴道转移、癌周淋巴管密度、生存率等临床病理特征密切相关。此外,实验动物模型与体外实验研究显示,抑制VEGF-C表达在胃癌治疗上具有一定的应用前景。现就VEGF-C与胃癌淋巴转移的相关性予以综述。Lymphatic vessel is a crucial pathway of tumor metastasis.With the more and more lymphatic vessel markers discovered,significant progress has been made in the study of the role of vascular endothelial growth factor-C（VEGF-C）and one of its specific receptors in the mechanisms of tumor lymphangiogenesis and lymph node metastasis.Moreover,it has demonstrated that VEGF-C expression is related to the clinicopathologic features of gastric cancer including lymph metastasis,microlymphatic vessel density in the adjacent carcinoma tissue,and the survival rate.The experimental animal models and in vitro experiments show that it will have a good prospect in the treatment of gastric cancer by the suppression of VEGF-C.This article gives an overview of the association between VEGF-C and lymph node metastasis of gastric cancer.

关 键 词：血管内皮生长因子C 血管内皮生长因子受体3 胃癌 淋巴结转移 

分 类 号：R735.2[医药卫生—肿瘤]