膀胱尿路上皮癌中Livin和Smac蛋白表达及意义  

Expression and clinical significance of Livin and Smac in urothelial carcinoma of the bladder

作　　者：王充[1] 李树国[1] 张延辉[1] 张哲[1] 孔垂泽[1] 刘贤奎[1] 

机构地区：[1]中国医科大学第一附属医院泌尿外科,沈阳110001

出　　处：《陕西医学杂志》2011年第1期98-101,共4页Shaanxi Medical Journal

基　　金：辽宁省科学技术攻关计划(2008225023)

摘　　要：目的:探讨膀胱尿路上皮癌中Livin和Smac蛋白表达及意义。方法:采用免疫印迹法(Western-Blot)检测Livin和Smac蛋白在73例膀胱尿路上皮癌及21例正常膀胱黏膜中的表达。结果:膀胱尿路上皮癌中Livin蛋白表达率(37.0%)高于正常膀胱黏膜(0%),Smac蛋白表达率(79.5%)低于正常膀胱黏膜(100%)。Livin蛋白表达率复发肿瘤高于初发肿瘤,Smac蛋白表达率低分期高于高分期。Livin和Smac蛋白表达呈负相关(r=-0.604,P<0.05)。结论:膀胱尿路上皮癌中Livin蛋白与复发相关,Smac蛋白与分期相关,可能成为肿瘤治疗的新靶点。Objective： To detect the expression of Livin and Smac and to discuss their clinical significance in urothelial carcinoma of the bladder.Methods： The expression of Livin and Smac were detected in 73 urothelial carcinoma of the bladder tissues and 21 normal bladder mucosa tissues by Western-Blot.Results： The expression rate of Livin in urothelial carcinoma of the bladder tissues（37.0%） was significantly higher than that in normal bladder mucosa tissues（0%）.The expression rate of Smac in normal bladder mucosa tissues（100%） was significantly higher than that in urothelial carcinoma of the bladder tissues（79.5%）.The expression rate of Livin in relapse tumors was higher than that in primary tumors.The expression rate of Smac in T1 was higher than that in T2~T4.The expression of Livin was significantly negatively correlated to the expression of Smac in urothelial carcinoma of the bladder and normal bladder mucosa（r=-0.604,P0.05）.Conclusion： Livin and Smac are closely related to the occurrence,progression and recurrence of urothelial carcinoma of the bladder,which may become new targets for cancer therapy.

关 键 词：膀胱肿瘤/诊断 膀胱肿瘤/病理学 抑制蛋白类/代谢 细胞凋亡 @Livin @Smac 

分 类 号：R737.14[医药卫生—肿瘤]