肝炎后肝硬化血清TNF-α、IL-6和IL-8检测的临床意义  

Clinical significance of detection of serum tumor necrosis factor、interleukin-6 and interleukin-8 in patients with posthepatitic cirrhosis

作　　者：马庭芳 闫秀英 胡海波 孟娟娟 郭霞 

机构地区：[1]山西省长治市人民医院消化内科,046000

出　　处：《中国现代医药杂志》2011年第1期61-62,共2页Modern Medicine Journal of China

摘　　要：目的探讨肝炎后肝硬化患者血清TNF-α、IL-6和IL-8的临床意义。方法 85例肝炎后肝硬化患者采用ELISA双抗体夹心法检测血清TNF-α、IL-6及IL-8水平,根据Child分级分为A(35例)、B(30例)、C(20例)3组,并与正常组(56例)相对照。结果肝炎后肝硬化组血清TNF-α、IL-6和IL-8水平较正常组明显升高(P<0.01),A、B、C三组各项指标比较差异显著(P<0.01)。结论血清TNF-α、IL-6和IL-8水平是反映肝炎后肝硬化肝功损害程度及判断病情预后的重要指标。Objective To explore the significance of serum tumor necrosis factor（TNF-α）,interleukin-6（IL-6） and interleukin-8（IL-8） in patients with posthepatitc cirrhosis.Methods Serum TNF-α,IL-6 and IL-8 were detected in 85 patients with posthepatitic cirrhosis by ELISA method.85 patients were assigned to A,B,C groups according to the Child grade and matched with control group.Results Serum TNF-α,IL-6 and IL-8 in patients with posthepatitic cirrhosis was higer than those in control group（P0.01）.There were significant differences among A,B,C groups（P0.01）.Conclusion Serum TNF-α,IL-6 and IL-8 are involved in damage of posthepatitic cirrhosis.

关 键 词：肝炎后肝硬化 肿瘤坏死因子 白细胞介素-6 白细胞介素-8 

分 类 号：R575.2[医药卫生—消化系统]