ACTH联合抗癫痫药物治疗婴儿痉挛症65例脑电图随访结果  

Long-term electroencephalogram outcomes of 65 children with infantile spasms treated with adrenocorticotropic hormone and other antiepileptic drugs

作　　者：陈荣芳[1] 吴德[1] 张功纯[1] 薛妹[1] 唐久来[1] 

机构地区：[1]安徽医科大学第一附属医院脑电图室,合肥230022

出　　处：《安徽医学》2011年第1期11-12,共2页Anhui Medical Journal

基　　金：安徽省卫生厅课题资助(09B096)

摘　　要：目的探讨婴儿痉挛症的脑电图动态改变,为临床治疗婴儿痉挛症提供神经电生理的依据。方法对65例确诊婴儿痉挛症的儿童,进行常规的ACTH联合抗癫痫药物治疗。分别在入院时、治疗后4周和6个月,进行脑电图的随访研究。结果治疗后4周,脑电图正常率达到47.54%(较入院时差异有统计学意义,校正χ2=42.979496,P<0.00),随访6个月,脑电图正常率为62.29%(与4周时比较χ2=2.681682,P=0.101508)。结论 ACTH联合抗癫痫药物治疗婴儿痉挛症脑电图好转明显。脑电图检查对于婴儿痉挛症的早期诊断并用来指导治疗、判定疗效及预后有重要意义。Objective To investigate the long-term electroencephalogram outcome of children with infantile spasm treated with adrenocorticotropic hormone and other antiepileptic drugs.Methods 65 children with infantile spasm were enrolled and treated with ACTH and Antiepileptic drugs.The electroencephalogram results were followed up at the baseline,four weeks after treatment and six months after treatment.Results 47.54% children with infantile spasms were found with normal electroencephalogram after four weeks treatment and normalization of EEG improved 62.29% after six months treatment（χ2= 2.681682,P=0.101508）.Conclusion Combined ACTH with other antiepileptic drugs is a good way to treat children with infantile spasms.

关 键 词：婴儿痉挛症 脑电图 高峰失律 

分 类 号：R742.1[医药卫生—神经病学与精神病学]