氢氧化钠瘤内注射对肝癌生长和转移抑制作用的实验性研究  

Therapeutic Effects of Intratumoral Injection of Sodium Hydroxide on Growth and Metastasis of Liver Cancer in Nude Mice Models

作　　者：严俊 陈伟 卢国锋 胡育新 陶文照[2] 

机构地区：[1]上海市嘉定区中心医院,201800 [2]第二军医大学长海医院病理科,200433

出　　处：《实用癌症杂志》2011年第1期10-12,共3页The Practical Journal of Cancer

基　　金：2006嘉定区科学技术委员会课题(2006JKK025)

摘　　要：目的探讨氢氧化钠溶液瘤内注射对肝癌的疗效及其毒副作用。方法对SMMU-LTNM肝癌裸鼠皮下模型,瘤内注射不同浓度的氢氧化钠溶液,与生理盐水组和无水酒精注射组比较(每组10只)肿瘤生长和肺转移抑制情况,并称动物体重。结果与生理盐水瘤内注射组相比,氢氧化钠注射组裸鼠体重显著增加,肿瘤生长和肺转移明显受抑制(P<0.05)。2%浓度组与3%浓度组抑瘤效果相近,优于1%浓度组(P<0.01),1%浓度组抑瘤效果与无水酒精注射组比较差异不显著(P=0.157)。结论 1%～3%浓度的氢氧化钠瘤内注射对肝癌具有较好的疗效,且无明显毒副作用。Objective To evaluate the therapeutic effects and side effects of intratumoral injection of sodium hydroxide.Methods Nude mice bearing subcutaneous SMMU-LTNM tumors were randomized into different concentrations of sodium hydroxide,normal saline,and ethanol groups（n= 10 for each group）.The inhibitive effects on tumor growth and lung metastasis were evaluated.The body weight was evaluated as well.Results 1% to 3% concentrations of sodium hydroxide could significantly inhibit tumor growth and lung metastasis,and increase the body weight of tumor-bearing mice（P0.05）.The effects on tumor growth was similar in 2% and 3% group,which were significantly better than that in 1% group（P0.01）,although its effects was not different from ethanol（P=0.157）.Conclusion Intratumoral injection with sodium hydroxide at the concentration between 1% to 3% is effective without side effects.

关 键 词：原发性肝癌 瘤内注射 氢氧化钠 无水酒精 

分 类 号：R735.7[医药卫生—肿瘤]