肾嫌色细胞癌5例临床病理学分析  

Chromophobe Cell Renal Carcinoma:a Clinicopathologic Analgsis of 5 Cases

作　　者：杜维[1] 聂长庆[1] 杨利民[1] 龚慧[1] 

机构地区：[1]湖南省常德市第一人民医院,415003

出　　处：《实用癌症杂志》2011年第1期63-65,68,共4页The Practical Journal of Cancer

摘　　要：目的探讨肾嫌色细胞癌的临床病理学特征,诊断和鉴别诊断要点及预后情况。方法回顾性分析5例肾嫌色细胞癌患者的临床资料和组织病理学特点,对肿瘤组织进行大体、光镜观察和免疫组化研究及Hale’s胶状铁染色,并复习相关文献和进行随访。结果 5例中男性3例,女性2例;年龄24～61岁,平均43.6岁;肿块直径3.5～10cm。镜下肿瘤由嫌色细胞和嗜酸细胞构成,呈实性片状、梁状和腺泡状分布。免疫组化:CK7(5/5),EMA(5/5),CD117(5/5),Ksp-cadherin(5/5),CD10(0/5),Vimentin(0/5),RCC(0/5),Ki-67计数<3%。Hale’s胶体铁染色阳性。随访23～97个月,5例患者均无肿瘤复发及转移,并存活至今。结论肾嫌色细胞癌是1种少见的肾肿瘤,预后较透明细胞型肾细胞癌好,与乳头状肾细胞癌相当;其特征性的组织学形态、免疫表型、Hale’s胶体铁染色和电镜及遗传学改变,为其诊断和鉴别诊断提供依据。Objective To investigate the clinicalpathologic features,key points of diagnosis and differential diagnosis and prognosis of chromophobe cell renal carcinoma（ChRCC）.Methods The clinicalpathological date were analyzed retrospectively in 5 patients with ChRCC.All cases of ChRCC were investigated by macroscopic observation and light microscopy and immunohistochemistry（IHC） and Hale＇s colloidal iron staining.with review of the relevant literature and follow-up.Results There were 3 male and 2 female patiens,aged from 24～61（mean age 43.6）.The sizes of tumors were from 3.5～10 cm.Histologically distributing by sheet,trabecular and alveolar patterns.The tumors were composed of chromophobe cells and eosinophilic cells.Immunohistochemically：the tumors expressed CK7（5/5）,EMA（5/5）,CD117（5/5）,Ksp-cadherin（5/5）,CD10（0/5）,Vimentin（0/5）,RCC（0/5）,Ki-67 index3%,respectively.Hale＇s colloidal iron positive stain.All the patients were followed for a period of 23～97months,and they were all alive,had no recurrence and metastasis.Conclusion Chromophobe cell renal carcinoma is a uncommon tumor.Its prognosis is better than that of clear cell renal carcinoma.but not different from papillary renal carcimoma.Its differential diagnosis must be established on the characteristics of pathology,immunohstochemical findings,Hale＇s colloidal iron staining,ultrastrucural and genetic changes.

关 键 词：肾肿瘤 嫌色细胞癌 免疫组织化学 临床病理分析 

分 类 号：R736.6[医药卫生—肿瘤]