阑尾杯状细胞类癌3例临床病理分析  

Goblet Cell Carcinoid of Appendix:a Clinicopathological Observation of 3 Cases

作　　者：李道胜[1] 班媛媛[1] 侯刚[1] 王青[1] 李静文[1] 

机构地区：[1]泰安市中心医院,271000

出　　处：《实用癌症杂志》2011年第1期81-82,共2页The Practical Journal of Cancer

摘　　要：目的探讨阑尾杯状细胞类癌的临床病理特点及免疫表型。方法对3例阑尾杯状细胞类癌进行组织学观察及免疫组化分析,并分析其临床资料。结果 3例阑尾杯状细胞类癌均为男性,平均年龄54岁,临床表现均为右下腹痛,术前均诊断为急性阑尾炎,肿瘤均位于阑尾尖部,平均直径为8.5 mm,组织学上由形态一致的杯状细胞形成巢状结构,呈浸润性生长,3例均侵及阑尾浆膜层。免疫表型:Syn及CgA均呈阳性,CK、NSE为局灶性阳性,CEA均为弥漫性阳性。随访至2010年6月均为无瘤生存。结论阑尾杯状细胞类癌是1种组织形态和免疫表型上具有外分泌和内分泌双重特点的肿瘤,较经典类癌更具侵袭性,需与腺癌鉴别。Objective To investigate the clinico-pathological features and immunological phenotypes of Goblet cell carcinoid of appendix（GCC）.Methods 3 cases of GCC were analyzed by histology,immunohistochemistry and clinical data.Results All 3 patients were men with an average age of 54 years.All patients presented right lower abdominal pain and were diagnosed as acute appendicitis preoperatively.The tumors were located at the tip of appendix and were measured about 8.5mm in diameter respectively.GCC was composed of uniform goblet cells which formed a nest pattern and exhibited an aggressive growthing.The serosal involvement was observed in 3 cases.Syn and CgA were positive in all cases.CK and NSE were focally positive.CEA was diffusely positive.Follow-up was performed until June 2010.All patients were alive free of this disease.Conclusion GCC has double characteristics of exocrine and endocrine tumors in mrophology and immunotype and has more aggressive behavior than classic carcinoids.It should be differentiated from adenocarcinoma

关 键 词：阑尾 神经内分泌 杯状细胞类癌 免疫组织化学 

分 类 号：R735.36[医药卫生—肿瘤]