原发性双侧乳腺癌7例临床分析  

Clinical Analysis on Bilateral Primary Breast Cancer with 7 Cases Report

作　　者：边明星 崔海潮[1] 邓国忠[1] 

机构地区：[1]江苏省阜宁县人民医院普外科,224400

出　　处：《医学理论与实践》2011年第1期11-12,36,共3页The Journal of Medical Theory and Practice

摘　　要：目的:探讨原发性双侧乳腺癌的临床特征、治疗和预后。方法:回顾我院1995年1月-2010年1月经病理组织学证实的7例原发性双侧乳腺癌患者的临床资料,结合文献复习对原发性双侧乳腺癌的诊断标准、发病率、病因及危险因素、治疗方式及预后进行讨论。结果:7例均符合原发性双侧乳腺癌的诊断标准,同时性1例,异时性6例,3例(42.86%)有家族史,第一癌发病年龄较轻,绝经前5例(71.43%),病理类型以浸润性导管癌和特殊类型为主,有2例(28.57%)ER、HER2、p53基因表达水平有差异,首发侧病期亦较早,经综合治疗后目前生存情况良好。结论:应重视双侧乳腺癌的发生,单侧乳腺癌发生后应积极随访以早期发现对侧病变,并采取综合治疗措施。Objective：To study the characteristics,treatment and the prognosis of bilateral primary breast cancer（BPBC）.Methods：Seven cases of BPBC patients underwent radical mastectomy from January 1995 to January 2010 in our unit were retrospectively analyzed.To evaluate diagnosis,incidence,etiology,risk factors,treatment and prognosis.Results：Seven cases all confirmed with diagnostic criteria of BPBC,including one presented simultaneous bilateral tumors and six developed bilateral breast cancer with interval.Three cases belonged to kindred breast cancer.Five cases got it before menopause as the age of patients suffering from the first breast cancer was trending younger.Pathological types of seven cases were mostly invasive ductal carcinoma or special types.The expressions of ER,HER2,p53 in two cases were different with whom the first cancer occurred earlier.All seven Patients were in good condition after surgery,radiation treatment and chemotherapy.Conclusion：One should take more care of the patients with unilateral breast cancer and beware of the possibility of BPBC,treating the patients with polytherapy once they are confirmed with BPBC.

关 键 词：双侧乳腺癌 原发性 诊断 治疗 

分 类 号：R737.9[医药卫生—肿瘤]