胰岛素样生长因子ⅡmRNA结合蛋白3在膀胱移行细胞癌的表达及意义  

Expression of insulin-like growth factor Ⅱ mRNA-binding protein 3 in transitional cell carcinoma of bladder and its clinical significance

作　　者：何学军[1] 刘文刚[2] 佘绍逸[2] 何上进[2] 邱前程[2] 刘文强[2] 

机构地区：[1]汕头大学医学院第一附属医院泌尿外科,515041 [2]汕头大学医学院2008级在校研究生

出　　处：《中国综合临床》2011年第1期82-85,共4页Clinical Medicine of China

摘　　要：目的 探讨胰岛素样生长因子ⅡmRNA结合蛋白3（IMP3）在膀胱移行细胞癌（BTCC）患者中的表达及其临床意义.方法 采用免疫组织化学方法检测48例BTCC患者（BTCC组）的标本及6例正常膀胱组织（对照组）中IMP3的表达情况,并分析其表达同患者年龄、性别、肿瘤的临床分期、病理分级的关系.结果 IMP3在BTCC组中的阳性表达率62.5%（30/48）明显高于对照组（表达均为阴性）,差异有统计学意义（χ2=8.615,P=0.003）;IMP3在浅表组（12/22,46.15%）、低级别组[G1级12.5%（1/8）,G2级60.0%（12/20）]表达明显低于其在浸润性（T2及以上,18/22,81.8%,P＜0.05）,高级别（17/20,85%,P＜0.05）膀胱移行细胞癌中的表达.结论 IMP3对于BTCC患者是一种非常有前景的肿瘤标志物,可用于BTCC的早期临床诊断及BTCC早期恶性程度的评估.Objective To investigate the expression of insulin-like growth factor Ⅱ mRNA-binding protein 3（ IMP3 ） in transitional cell carcinoma of bladder（ TCCB ） and its clinical significance. Methods The IMP3 expressions in 6 normal bladder tissues and 48 TCCB tissues were determined by immunohistochemistry staining, and the relationships between IMP3 expression and gender, age, pathological grading and staging were analyzed statistically. Results The positive expression rate of IMP3 was 62.5% （ 30/48 ） in bladder cancer,which were significantly higher than that in normal control （ 0/6 ） （ P 〈 0. 05 ）. The positive rate of IMP3 expression were significantly lower in superficial TCCB （ 46. 15%, 12/22 ） or early TCCB [ Grade Ⅰ 12. 5%（1/8） ,Grade Ⅱ 60. 0% （12/20） ] than that in invasive TCCB [T2 or above,81.8% （18/22） ] or advanced TCCB [ Grade Ⅲ ,85% （ 17/20 ） ] （ Ps 〈 0. 05 ）. Conclusion IMP3 is a promising biomarker for eraly detection and assessment of the malignancy degree in TCCB.

关 键 词：膀胱移行细胞癌 胰岛素样生长因子Ⅱ mRNA结合蛋白3 免疫组织化学法 

分 类 号：R737.14[医药卫生—肿瘤]