CD83、Ki-67在大肠癌中的表达及预后意义  

Expressions of CD83,Ki-67 in colorectal carcinoma and its prognostic significance

作　　者：黄良勤[1] 杨伟明[2] 刘宙[2] 赵洪远[2] 王超宇[2] 邬江华[2] 梁爽[3] 

机构地区：[1]遵义医学院生理教研室 [2]遵义医学院附属医院甲状腺乳腺外科,563003 [3]华北油田华苑医院妇产科,河北河间062450

出　　处：《重庆医学》2011年第3期221-223,F0002,共4页Chongqing medicine

基　　金：贵州省优秀科技教育人才省长专项资金资助项目[(2007)79];贵州省卫生厅科学技术基金资助项目[D-280];遵义医学院附属医院硕士启动基金资助项目[(2008)33]

摘　　要：目的探讨CD83、Ki-67在大肠癌组织中的表达及对预后的意义。方法收集大于或等于5年生存组和小于3年死亡组大肠癌病例各30例,用免疫组化和流式细胞术检测大肠癌组织中CD83、Ki-67的表达,分析其与大肠癌临床病理特点和预后的关系。结果免疫组化检测显示,CD83的表达随着Dukes分期的升高而降低,≥5年生存组表达明显高于小于3年死亡组(P<0.05);Ki-67的表达随着Dukes分期的升高而增高,≥5年生存组表达明显低于小于3年死亡组(P<0.05)。流式细胞术检测显示,CD83在A期和B期中的表达明显高于C期和D期(P<0.05);Ki-67在A期和B期中的表达明显低于C期和D期(P<0.05)。结论大肠癌中CD83、Ki-67表达与预后相关,可以作为检测大肠癌预后的参考指标。Objective To investigate the CD83,Ki-67 in colorectal carcinoma and its prognostic significance.Methods ≥ 5-year survival group and death group 3 years,30 cases of colorectal cancer patients,used immunohistochemical staining and flow cytometry to detect colorectal cancer CD83,Ki-67 expression analysis with clinical pathology of colorectal cancer characteristics and prognosis.Results Immunohistochemistry showed that CD83 expression increased with Dukes staging decreasad,≥ 5-year survival group expressed higher than the 3-year death group（P0.05）;Ki-67 expression increased with Dukes staging increased,≥ 5-year survival group expressed less than the 3-year death group（P0.05）.Flow cytometry showed that in different points during the Dukes colorectal,CD83 expression in colorectal cancer tissues in A phase and B phase was significantly higher than C phase and D phase colorectal cancer organizations（P0.05）;Ki-67 A phase and B phase colorectal cancer tissues was significantly lower than Phase C phase and D phase in colorectal cancer（P0.05）.Groups of ≥ 5 year survival than Ki-67 expression in 3-years of death group（P0.05）.Conclusion Colorectal CD83,Ki-67 expression and prognosis related to detection of colorectal cancer prognosis can be used as a reference indicator.

关 键 词：结直肠肿瘤 预后 KI-67抗原 CD83 

分 类 号：R735.34[医药卫生—肿瘤]