bFGF、FGFR-1在外阴鳞状上皮增生组织中表达及意义  

Expression of bFGF and FGFR-1 in Vulvar Squamous Cell Hyperplasia

作　　者：赖慧敏[1,2] 邓新粮[1] 薛敏[1] 孙信[1] 

机构地区：[1]中南大学湘雅三医院妇科,湖南长沙410013 [2]湖南省株洲市一医院妇产科

出　　处：《实用预防医学》2011年第1期22-25,共4页Practical Preventive Medicine

摘　　要：目的分析聚焦超声(HIFU)治疗对外阴鳞状上皮细胞增生组织中bFGF和FGFR-1表达的影响,探讨其可能的治疗机制。方法采用免疫组化SABC法,检测30例患者治疗前后外阴鳞状上皮细胞增生组织中碱性成纤维细胞生长因子(bFGF)及其受体成纤维细胞生长因子受体-1(FGFR-1)的表达。结果外阴鳞状上皮细胞增生病损区皮肤bFGF及FGFR-1表达均较正常皮肤组织明显降低(分别为16.7%、46.7%),差异有统计学意义(P<0.05),聚焦超声治疗后1月,bFGF及FGFR-1的表达均较治疗前显著增高(分别为86.7%、80%)(P<0.01),患者治疗后3个月病变部位bFGF、FGFR-1表达与外阴正常部位皮肤及正常女性外阴皮肤比较差异无统计学意义(P>0.05)。结论 1.HIFU能有效提高组织中bFGF、FGFR-1的表达,可能是治疗外阴鳞状上皮细胞增生的分子机制之一。2.bFGF、FGFR-1表达的降低可能与外阴鳞状上皮细胞增生的发病有关。Objective To explore the expression of bFGF and FGFR-1 before and after the therapy of HIFU in vulvar squamous cell hyperplasia,and to found out the possible mechanism. Methods bFGF and FGFR-1 were positively expressed in the vulvae of 30 patients before and after HIFU treatment by the immunohistochemistry method,which were used to evaluate the possible mechanism. Results The expression of FGFR-1 in lesions of SH（4/30,13.3%） was significantly lower than that in normal skin（13/30,43.3%）,（P0.05）.The expression of bFGF in lesions of SH（5/30,16.7%） was significantly lower than that in normal skin（14/30,46.7%）,（P0.05）.One month after the treatment,the expression of bFGF（26/30,86.7%） and FGFR-1（24/30,80%） was increased significantly,（P0.01）. Three month after the treatment,no statistically significant difference was found in the expression of bFGF and FGFR-1 between normal vulvae of the patients and vulvae of normal women（P0.05）. Conclusions HIFU can effectively improve the expression of bFGF and FGFR-1,which may be one of the most important mechanisms of its therapy.The decreasing of the expression of bFGF and FGFR-1 may be related to the onset of vulvar squamous cell hyperplasia.

关 键 词：高强度聚焦超声 外阴鳞状上皮细胞增生 BFGF FGFR-1 

分 类 号：R711.72[医药卫生—妇产科学]