provided by the National Natural Science Foundation of China(Nos.21222211,21372001,91313303);the Program for New Century Excellent Talents in University(No.NCET-12-0853);the Fundamental Research Funds for the Central Universities are gratefully acknowledged
A series of novel, cycloalkyl-modified pazopanib analogs 2 and 3 were designed and synthesized. Their kinase modulatory effects on FGFR-1, VEGFR-2, PDGFR-β and c-KIT were evaluated by the caliper mobility shift assay...