云南高校图书馆联盟文献共享服务平台- CYCLIN

CYCLIN: 作品数：1051被引量：3494H指数：18; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：姚晖岳利民张金虎何亚平梁卫江更多>>; 相关机构：华中科技大学武汉大学中国医科大学中国医科大学附属第一医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家教育部博士点基金更多>>

益肾健骨丸对膝骨关节炎大鼠软骨组织AMPK/Cyclin Y/CDK16通路表达及软骨细胞自噬、凋亡的影响: 《中国中医药信息杂志》2024年第10期89-95,共7页柴喜平李盛华周明旺陈威宋学文柴英英; 甘肃省自然科学基金(22JR5RA634);国家中医药管理局高水平重点学科(中医骨伤科学)建设项目(203)。; 目的观察益肾健骨丸对膝骨关节炎(KOA)大鼠软骨组织AMPK/Cyclin Y/CDK16通路及软骨细胞自噬、凋亡相关蛋白表达的影响,探讨其治疗KOA的作用机制。方法将60只2月龄SD大鼠随机分为假手术组、模型组、激动剂组和中药低、中、高剂量组,每组1...; 关键词：膝骨关节炎益肾健骨丸软骨细胞自噬 AMPK通路大鼠

miR-199a通过干预心肌细胞周期对心肌梗死的调控作用: 《中国老年学杂志》2024年第17期4271-4274,共4页贾慧宇常永峰韩培天徐俊华; 河北省医学科学研究课题(20200498)。; 目的探究miR-199a通过干预细胞周期通路对心肌梗死的调控作用机制。方法将SPF级Balb/c小鼠分为对照组、模型组和miR-199a组各10只,模型组和miR-199a组建立心肌梗死模型,miR-199a组建模后尾静脉注射miR-199a质粒,模型组注射等量生理盐水,...; 关键词：心肌梗死心肌细胞细胞凋亡细胞周期细胞周期调控因子G1/S-特异性周期蛋白(Cyclin)D1

Cadaverine and putrescine exposure influence carbon and nitrogen cycling genes in water and sediment of the Yellow River: 《Journal of Environmental Sciences》2024年第8期236-247,共12页Wanghong Su Qiaoling Yu Jiawei Yang Qian Han Sijie Wang Petr Hedenec Xiaochen Wang Ruijun Wan-Yan Huan Li; supported by the National Natural Science Foundation of China(No.42007026);the Medical Innovation and Development Project of Lanzhou University(No.lzuyxcx-2022-172)。; The response patterns of microbial functional genes involved in biogeochemical cycles to cadaver decay is a central topic of recent environmental sciences.However,the response mechanisms and pathways of the functional...; 关键词：Carbon cycling Nitrogen cycling CADAVERINE PUTRESCINE Pollution management

MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer: 《Journal of Pharmaceutical Analysis》2024年第6期863-877,共15页Haowei Zhang Qixin Li Xiaolong Guo Hong Wu Chenhao Hu Gaixia Liu Tianyu Yu Xiake Hu Quanpeng Qiu Gang Guo Junjun She Yinnan Chen; supported by grants from the National Natural Science Foundation of China(Grant Nos.:82003807,82173394);the Shaanxi Province Science Foundation,China(Grant No.:2023-GHZD-19);the Medical Foundation-Clinical Integration Program of Xi'an Jiaotong University,China(Grant No.:YXJLRH2022043);the Xi'an Jiaotong University Free Exploration and Innovation-Teacher Project Foundation,China(Grant No.:xzy012023104).; Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer(CRC).Cisplatin(DDP)-resistant cells exhibit an inherent ability to evade the toxic chemotherapeu...; 关键词：Colorectal cancer MGMT Chemotherapy resistance Slow-cycling cells Nonhomologous end joining Wnt pathway

Cell division cyclin 25C knockdown inhibits hepatocellular carcinoma development by inducing endoplasmic reticulum stress: 《World Journal of Gastroenterology》2024年第19期2564-2574,共11页Yan-Fei Li Fang-Yuan Zheng Xin-Yu Miao Hai-Long Liu Yao-Yao Zhang Nai-Xia Chao Fa-Rong Mo; Supported by Natural Science Foundation of Guangxi Zhuang Autonomous Region,China,No.2023GXNSFAA026070 and No.2018GXNSFAA281071.; BACKGROUND Cell division cyclin 25C(CDC25C)is a protein that plays a critical role in the cell cycle,specifically in the transition from the G2 phase to the M phase.Recent research has shown that CDC25C could be a pot...; 关键词：Cell division cyclin 25C Hepatocellular carcinoma Endoplasmic reticulum stress PROLIFERATION Apoptosis

自组装FeRu双金属纳米催化剂在可逆固体氧化物电池中实现高效稳定的CO-CO_(2)相互转化被引量：1: 《Science China Materials》2024年第5期1471-1480,共10页王晶张栋刘通徐安琪罗瑶胡学雷王瑶; supported by the start-up research funds from Wuhan Institute of Technology(K202201);Natural Science Foundation of Hubei Province of China(2024CFB755);National Natural Science Foundation of China(U21A20317);the Graduate Innovation Fund of Wuhan Institute of Technology(CX2023040)。; 本文报道了一种适应于高效稳定的CO-CO_(2)相互转化的可逆固体氧化物电池(RSOC)相变燃料电极.该燃料电极由FeRu双金属纳米催化剂和Ruddlesden-Popper相Pr_(0.8)Sr_(1.2)Fe_(1-x-y)Ru_(x)Mo_(y)O_(4)氧化物复合而成(FeRu@PSFRM).固体氧...; 关键词：Ruddlesden-Popper oxide CO-CO_(2)conversion cycling test perovskite oxide reversible solid oxide cells distribution of relaxation times electrochemical impedance spectra fuel electrode

Metagenomic Insight Reveals the Microbial Structure and Function of the Full-Scale Coking Wastewater Treatment System:Gene-Based Nitrogen Removal被引量：1: 《Engineering》2024年第5期76-89,共14页Jiaying Ma Fan Wang Haifeng Fan Enchao Li Huaqiang Chu Xuefei Zhou Yalei Zhang; financially supported by the National Natural Science Foundation of China(52270076 and 51922078);the China Baowu Low Carbon Metallurgy Innovation Foundation(BWLCF202105).; Microbial communities play crucial roles in pollutant removal and system stability in biological systems for coking wastewater(CWW)treatment,but a comprehensive understanding of their structure and functions is still ...; 关键词：Coking wastewater FULL-SCALE Microbial community Metagenomic sequencing Nitrogen-cycling genes Environmental factor

Potential role of cyclin‑dependent kinase 4/6 inhibitors in the treatment of mucosal melanoma: 《Holistic Integrative Oncology》2024年第1期462-475,共14页Chaoji Shi Houyu Ju Yunteng Wu Xuhui Ma Zhiyuan Zhang Guoxin Ren; supported by the Shanghai Clinical Research Center for Oral Diseases(19MC1910600);CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-I2M-5-037);Shanghai Clinical Research Center for Oral Diseases(19MC1910600);Shanghai’s Top Priority Research Center(2022ZZ01017);Fundamental research program funding of Ninth People’s Hospital affiliated to Shanghai Jiao Tong university School of Medicine(JYZZ187).; Mucosal melanoma(MM)is a rare and aggressive form of melanoma with a poorer prognosis compared to other subtypes.Recent large-scale next-generation sequencing studies,including our own research,have demonstrated that ...; 关键词：Mucosal melanoma CDK4/6 inhibitors Cyclin-dependent kinases Clinical trial IMMUNOTHERAPY

益肾健骨丸对KOA软骨细胞AMPK/Cyclin Y/CDK16通路活性及细胞自噬的影响: 《时珍国医国药》2024年第1期60-65,共6页柴喜平李盛华周明旺陈威朱保红柴英英; 甘肃省自然科学基金(22JR5RA634)。; 目的探讨益肾健骨丸对膝骨关节炎(KOA)软骨细胞AMPK/Cyclin Y/CDK16通路活性及自噬的影响。方法在接受人工全膝关节置换术KOA患者软骨组织中提取软骨细胞,筛选最佳给药浓度及时间后,将其分成模型组(Modle)、对照组(Control)、AMPK激...; 关键词：膝骨关节炎软骨细胞自噬 AMPK通路益肾健骨丸

Discovery of small molecule degraders for modulating cell cycle: 《Frontiers of Medicine》2023年第5期823-854,共32页Liguo Wang Zhouli Yang Guangchen Li Yongbo Liu Chao Ai Yu Rao; supported by National Key R&D Program of China (Nos.2021YFA1302100,2020YFE0202200,and 2021YFA1300200);National Natural Science Foundation of China (No.82125034);Fellowship of China Postdoctoral Science Foundation (No.2021M701953);the Foundation of Shuimu Tsinghua Scholar Program (No.2021SM110).; The cell cycle is a complex process that involves DNA replication,protein expression,and cell division.Dysregulation of the cell cycle is associated with various diseases.Cyclin-dependent kinases(CDKs)and their corres...; 关键词：PROTAC molecular glue degrader cell cycle CDK CYCLIN

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