参草扶正抗癌冲剂用于晚期非小细胞肺癌化疗的研究  

Study on Shencao Fuzheng Kangai granules in treatment of advanced non-small cell lung cancer

作　　者：徐岗[1] 王远东[1] 邓晓芳[1] 闫冰川[1] 

机构地区：[1]广州医学院附属肿瘤医院,广东广州510095

出　　处：《现代中西医结合杂志》2011年第3期261-262,292,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广州市中医药;中西医结合科研立项课题(2008a61)

摘　　要：目的评价参草扶正抗癌冲剂辅助化疗治疗晚期非小细胞肺癌的近期疗效及不良反应。方法 50例晚期非小细胞肺癌患者随机分为实验组和对照组,每组25例,2组均行化疗,初治患者采用紫杉醇+顺铂,复治患者采用单药多西紫杉醇治疗,21 d为1个周期,实验组化疗同时辨证施治服用参草扶正抗癌冲剂。完成2周期化疗后3周做疗效评价。结果实验组有效率48%,对照组有效率36%,2组比较无显著性差异(P>0.05);实验组恶心、呕吐发生率较对照组明显降低(P<0.05);2组患者白细胞下降、血红蛋白下降、血小板下降、肝肾功能损害发生率比较无显著性差异(P均>0.05),但对照组白细胞和血红蛋白的Ⅲ～Ⅳ度抑制率明显高于实验组(P均<0.05);2组生活质量提高+稳定率比较有显著性差异(P<0.05)。结论参草扶正抗癌冲剂辅助晚期非小细胞肺癌化疗,可以增强疗效,减轻毒副反应,改善患者生活质量。Objective It is to evaluate the efficacy and side effects of Shencao Fuzheng Kangai granules（SFKG） combined with chemotherapy in treatment of advanced non-small cell lung cancer（CSCLC）.Methods 50 patients with NSCLC were randomly divided into test group with 25 cases for chemotherapy plus SFKG and control group with 25 cases for chemotherapy only.The chemotherapy regimen of previously untreated patients was paclitaxel and cisplatin,and the others used docetaxel.The chemotherapy was repeated every 21 days.The efficacy and side effects were evaluated in 3 weeks after two courses of chemotherapy.Results The response rate was 48% in the test group and 36% in the control group.No difference was found between the both groups（P〉0.05）.The incidence rate of nausea and vomit in test group was obviously lower than that in control group（P〈0.05）.The side effects included white blood drop,hemoglobin drop,platelet drop,hepatic and renal insufficiency were not significant different between the two groups（P〉0.05）.There was significant different in the quality of life and stability between the two groups（P〈0.05）.Conclusion SFKG plus chemotherapy is effective for advanced NSCLC.It can release the side effect and improve the quality of life of patients.

关 键 词：参草扶正抗癌冲剂 晚期非小细胞肺癌 化疗 

分 类 号：R734.2[医药卫生—肿瘤]