纳他霉素滴眼剂对兔眼的刺激性研究  

Irritation of natamycin on rabbit eyes

作　　者：董贤慧[1] 钱涛[1] 高维娟[1] 贺小平[1] 

机构地区：[1]承德医学院病理生理学教研室,河北承德067000

出　　处：《华西药学杂志》2011年第1期34-35,共2页West China Journal of Pharmaceutical Sciences

基　　金：国家科技支撑计划重大项目(批准号:2007BAI26B07)

摘　　要：目的探讨纳他霉素滴眼剂对正常兔眼的刺激性。方法将20只新西兰白兔随机均分为那特真组、生理盐水组、纳他霉素滴眼剂组、赋形剂组。每组10只兔眼,每天用药8～10次,每次1滴,连续应用至第21天,停药后观察2 d。采用双盲法用裂隙灯观察兔眼刺激情况并评分。结果各实验组药物对正常兔眼均无刺激性,与生理盐水组比较,均无显著差异。结论纳他霉素滴眼剂对兔眼无刺激性,有着良好的发展前景。OBJECTIVE To investigate the irritation of natamycin on normal rabbit eyes and to provide experimental basis for the application of clinical safety.METHODS 10 rabbit eyes of each group were dropped respectively by natamycin,natacyn,normal saline and vehicle eyedrops.The irritation of eyes was double-blinded evaluated by slit-lamp examinations and scored.RESULTS The results showed that there was not irritation in any experimental groups,and no significant differences compared with normal saline control group.CONCLUSION Natamycn as a kind of effective against fungal keratitis,with low toxicity on eyes is of great prospect.

关 键 词：抗真菌药 纳他霉素 那特真 刺激性 

分 类 号：R96[医药卫生—药理学]