迷走背核微量注射P物质抑制大鼠胃肌电活动和胃运动  

INHIBITION OF GASTRIC MYOELECTRIC ACTIVITY AND GASTRIC MOTILITY BY MICROINJECTION OF SUBSTANCE P INTO DORSAL VAGAL NUCLEUS IN RATS

作　　者：彭岩[1] 林坤伟[1] 

机构地区：[1]大连医科大学生理教研室,大连116027

出　　处：《生理学报》1999年第5期557-563,共7页Acta Physiologica Sinica

摘　　要：本工作观察到大鼠迷走背核微量注射P物质（SubstanceP，SP）抑制胃肌电快波和胃运动。该效应可分别被迷走背核注射SP抗血清、SP受体拮抗剂[Arg6，D-Trp7.9，N-Me－Phe8]－SP6-11或切断迷走神经所消除。用利血平耗竭交感神经递质则不影响该效应。结果表明：迷走背核外源性和内源性SP均抑制胃肌电和胃运动，且通过其受体起作用；迷走背核SP的抑胃效应系通过迷走神经传出。The Present inveshgation showed tha ndcroinjechon of substance P (SP) into dohalVagal nucleus inhibited gastric mpelectric fast wav and gastric rnohlity. The effect coLildbe blocked by SP antisennn or SP antagonist [Arg, D-Trp7,9, N-Me-Phe8 ]-SP6-11 orvagotomy. Depletion of sympathehc hansndtters by reserpine did not det induchon ofthe idebihon. The results indicate tha both exognous and endogenous SP of dorsal vagalnucleus decrease the gastric myoelectric fast wav and mohlity, Which is mediated byvagus nerve.

关 键 词：迷走背核 P物质 胃肌电 胃运动 SP抗血清 

分 类 号：Q482[生物学—生理学] R333.2[医药卫生—人体生理学]