supported by the National Key Research and Development Program of China(ZHU Jin-Xia,No.2016YFC1302203);Beijing Municipal Natural Science Foundation(ZHU Jin-Xia,No.7182014;ZHENG Li-Fei,No.5172006);the National Natural Science Foundation of China(ZHENG Li-Fei,No.31400991);Teaching and Scientific Research Cultivation Project of Basic Medical College of Xinxiang Medical College(ZHOU Li,No.JCYXYKY202018)。