下丘脑减压区微量注射牛磺酸对血压的影响  

EFFECT OF MICROINJECTION OF TAURINE INTO ANTERIOR HYPOTHALAMIC AREA ON BLOOD PRESSURE IN RATS

作　　者：陈蕾[1] 李荣娟[2] 周颖斌[1] 陈家津[1] 

机构地区：[1]青岛大学医学院生理学教研室,青岛266021 [2]青岛疗养院检验科,青岛266000

出　　处：《生理学报》1999年第5期593-596,共4页Acta Physiologica Sinica

摘　　要：实验来用微量注射和荧光分光光度测定的方法，探讨了下丘脑前部减压区牛磷酸对大鼠血压的影响及其可能的机制。结果显示：（1）下丘脑前部减压区微量注射牛磺酸可致大鼠血压降低（P＜0．01）；（2）侧脑室注射β受体阻断剂心得安可阻断牛磺酸的降压效应（P＜0．01），而α受体阻断剂酚妥拉明对牛磺酸的降压效应无明显影响（P＞0．05）；（3）下丘脑前部减压区注射牛磺酸后，可使下丘脑去申肾上腺素含量明显增高（P＜0．05）。结果提示，下丘脑前部减压区注射牛磷酸可降低大鼠血压，其机制可能是通过去甲肾上腺素合成或释放增加，并作用于β受体而发挥作用。The effect of tadrine in anterior hppdsc area (AHA) on bbo pressare wasinveshgated by means of ndcroinjechon and specbophotoflmemeny. The results are asfollow. (1) Taurine ndcroinjected into ou deced blood presare markedly. (2)The depressor response of taurine in AHA could be antagnized by propenolol, but not byphentoldrine. (3) After ndcroinjection of tadrine into AHA, the content ofnorepinephrine in Wamus increased significanily. The aboe results suggest thattaurine in AHA attenuates blood pressare by increasing the content of norepinephrine,probably mediated by β-adrineopc receptor.

关 键 词：牛磺酸 下丘脑前部 减压区 血压 

分 类 号：R338.7[医药卫生—人体生理学] R338.27[医药卫生—基础医学]