唐山市住院精神分裂症患者抗精神病药物联合治疗调查  

Antipsychotics combined use pattern among schizophrenic inpatients in Tangshan region

作　　者：徐广明[1] 肖水源[2] 费立鹏[3] 谷岩[4] 张本[4] 李建明[5] 徐建国[6] 刘涛 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,长沙410011 [2]中南大学湘雅二医院公共卫生学院,长沙410011 [3]北京回龙观医院北京自杀研究与干预中心 [4]华北煤炭医学院附属开滦精神卫生中心 [5]华北煤炭医学院心用心理学系 [6]唐山市第五医院 [7]唐山市心理医院

出　　处：《中华行为医学与脑科学杂志》2010年第11期989-991,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：NIMH 中国自杀研究合作培训项目（5D43TW007273-02）

摘　　要：目的 分析住院精神分裂症患者抗精神病药物联合治疗率及影响因素.方法 调查1986,1996,2001和2006年4个年份在唐山市6所精神病院出院精神分裂症患者的住院病历,用专门设计的调查表记录患者的社会人口学资料、疾病特征以及患者出院时药物治疗信息.结果 4个年份住院精神分裂症患者出院时抗精神病药物联合治疗率分别为13.2%、18.1%、32.7%和28.9%,差异有显著性（x2=76.431,df=1,P＜0.01;趋势卡方检验x2=25.542,df=1,P＜0.01）;多因素分析表明患者的病程（＜18月∶OR=0.686,95%CI∶0.528～0.893,ref：＞100月）,住院次数（OR=1.117,95%CI∶1.037～1.203）,就诊医院（市级A医院：OR=0.736,95%CI∶0.562～0.964;市级B医院∶OR=0.377,95%CI∶0.293～0.486;市级C医院：OR=1.803,95%CI∶1.279～2.540,ref：县级医院）、以及出院年份（1986∶OR=0.421,95%CI∶0.298～0.595;1996∶OR=0.590,95%CI∶0.456～0.764;2001∶OR=1.249,95%CI∶1.023～1.524,ref∶2006）与接受抗精神病药物联合治疗有关.结论 唐山地区住院精神分裂症患者联合抗精神病药物治疗的比例呈上升趋势,抗精神病药物联合治疗率存在医院差别,患者的发病年龄、病程、住院时间和住院次数与抗精神病药物联合治疗有关.Objective To investigate rates and clinical associates of combined antipsychotic therapy in hospitalized patients with schizophrenia during 1986 ～ 2006. Methods Hospital charts of schizophrenic inpatients who discharged from six psychiatric hospitals in Tangshan in 1986,1996,2001, and 2006 were reviewed. Demographic and clinical character and prescription information at time of discharged of patients＇ was coded by trained investigators with a special designed form. Results The rates of combination antipsychotic therapy in the four years mentioned above were 13.2%, 18. 1% ,32.7%, and 28.9% ,respectively and the difference was statistically significant（ x2 = 76.431, P 〈 0.01; linear by linear x2 = 25. 542, P 〈 0.01 ）. Combined antipsychotic therapy in schizophrenic inpatients in Tangshan region show a increasing trend. There is significant difference of rate of combined antipsychotic therapy between hospitals. Combined antipsychotic therapy were associated with duration of illness,numbers of prior psychiatric hospital admission,hospital from which patients discharged,and discharged year.

关 键 词：精神分裂症 住院患者 抗精神病药物 联合治疗 预测因素 

分 类 号：R749.3[医药卫生—神经病学与精神病学]