脑梗死患者情景记忆编码损伤研究  

The study about impairment of episodic memory encoding in patients with cerebral infarction

作　　者：郭宗君[1] 肖琳[1] 田玉波[2] 于焕清[1] 章政[1] 邢昂[1] 王强[3] 

机构地区：[1]青岛大学医学院附属医院特需保健科,青岛266003 [2]青岛大学医学院附属医院神经内科,青岛266003 [3]青岛大学医学院附属医院康复医学科,青岛266003

出　　处：《中华行为医学与脑科学杂志》2010年第12期1060-1062,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项目：国家“十一五”科技支撑计划（2006BA102801）;山东省科技厅基金资助项目（22130109）;青岛市科技局基金资助项目（Kzd03.09-1-1-33-nsh）

摘　　要：目的探讨脑梗死患者情景记忆编码损伤及其相关影响因素。方法急性期病情稳定的脑梗死患者（112例），与正常对照组（115例）比较：各组均按要求在计算机上完成情景记忆编码测试，观察各组情景记忆编码成绩的变化以及相关因素的影响。，结果脑梗死组情景记忆编码成绩记住数（REM）明显低于对照组[（70．81±6．08）％，（84．67±4．49）％，P〈0．01）]；额叶梗死组、颞叶梗死组、基底节梗死组及放射冠梗死组四组REM差异具有显著性[（65．88±5．73）％，（68．92±4．65）％，（73．39±6．20）％，（73．53±3．44）％，p〈0．01）]，额叶梗死组低于颞叶梗死组（P〈0．05），颞叶梗死组低于基底节区梗死组及放射冠梗死组（P〈0．05，P〈0．01）；皮层梗死组低予皮层下梗死组[（67．37±5．40）％，（73．46±4．99）％，（P〈0．01）]：脑梗死小病灶组REM高于脑梗死大病灶组[（72．67±4．47）％，（67．56±6．18）％，P〈0．01）]，且病灶直径大小与REM具有显著相天性（r=一0．39）=对照组、脑梗死伴腑萎缩与脑梗死无脑萎缩三组REM差异具有显著性（P〈0．01），脑梗死伴脑萎缩组REM低于脑梗死无脑萎缩组和对照组，差异具有显著性（均P〈0．01）；脑梗死无脑萎缩组REM低于对照绀，差异具有显著性（P〈0．01）。结论脑梗死患者存在情景记忆编码损害，梗死部位、梗死灶大小以及有无脑萎缩与情景记忆编码损害有关，Objective To investigate the impairment and the eft^ct factors of encoding of episodic memory in patients with cerebral infarction. Methods 112 cases cerebral infarction patients and 115 healthy eiders as controls were tested for episodic memory encoding with episodic pictures accomplished in computer, and compare the differences of encoding of episodic memory between the two groups. Results The remember indexes（REM） of encoding memory test in patient group was significantly lower than that in control group（ （70. 81±6.08 ）vs （84.67 ± 4.49）, P 〈 0. 01 ）. The REM in patients with different impaired areas was significantly different （ （ 65.88 ± 5.73 ）, （ 68.92 ± 4.65 ）, （ 73.39 ± 6.20 ）, （ 73.53 ± 3.44 ）, P 〈 0.01 ）. The REM in frontal lobe infaretion group was signifieant]） lower than that in temporal lobe infarction group（P 〈 0.05 ）, and in temporal lobe infarction group was significantly lower than that in basal ganglia infarction group and corona radiate infarction group （P〈0. 05, P〈0. 0l ）. The REM in cortex infarction group was significantly lower than that in under cortex group （ （ 67.37 ± 5.40） , （ 73.46 ± 4.99 ） , P 〈 0.01 ）. The REM in small cerebral infarction group was significantly higher than that in large cerebral infarction group （ （ 72.67± 4.47 ）, （ 67.56 ± 6.18 ）, P 〈 0.01 ）. The size of cerebral infarction diameter was related with the REM （ r = - 0.39, P 〈 0.01 ）. The REM among control group,infarction with atrophy group, and infarction without atrophy gronp were significantly different （ （ 67.03±6. 17 ）, （72.84 ±5.00）, （84.67±4.49）, P〈0. 01 ）. The REM in infarction with atrophy group was significantly lower than that in infarction without atrophy group and control group （both P〈 0.01 ） ,The REM in infarction without atrophy group was significantly lower than that in control group （P 〈 0. 01 ）. Conclusion The encoding of episodic memory was impaired in cerebral infa

关 键 词：脑梗死 情景记忆 编码 脑萎缩 

分 类 号：R743.3[医药卫生—神经病学与精神病学]