序贯心理治疗合并5-羟色胺再摄取抑制剂治疗难治性强迫症的临床疗效  

Clinical efficacy of sequential psychotherapy combined with selective serotonin reuptake inhibitors on re- fractory obsessive-compulsive disorder

作　　者：周朝昀[1] 耿德勤[2] 沙维伟 张晓斌 董晓星 房才龙[4] 

机构地区：[1]徐州医学院,徐州221002 [2]徐州医学院附属医院 [3]江苏省扬州五台山医院 [4]英国伦敦大学国王学院医学院

出　　处：《中华行为医学与脑科学杂志》2010年第12期1066-1068,共3页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的探讨序贯心理治疗合并5-羟色胺再摄取抑制剂（SSRIs）治疗难治性强迫症的疗效。方法对50例难治性强迫症患者在原SSRIs类药物治疗的基础上给予序贯心理治疗，在第一阶段、第二阶段、第三阶段分别给予精神分析疗法、森田疗法／认知行为疗法、现实疗法。每阶段疗程8周。采用Yale—Brown强迫量表分别在治疗前、治疗第8周末、治疗第16周末及治疗第24周末各评定1次，并进行对比分析。结果治疗前及治疗第24周末Yale—Brown强迫量表分别为[（21．10±4．69）分]和[（10．18±6．14）分]。第24周末Yale—Brown强迫量表减分率判定痊愈率34．0％（17／50），显进率42．0％（21／50）。结论在SSRIs类药物治疗的基础上给予序贯心理治疗是治疗难治性强迫症一种有效的方法。Objective To evaluate the efficacy of sequential psychotherapy combined with selective serotonin reuptake inhibitors（SSRI）s on refractory obsessive-compulsive disorder（OCD）. Methods 50 patients with refractory OCD were given to sequential psycho therapy in the original basis of the SSRIs drugs treatment. The patients were given psychoanalysis,cognitive behavioral therapy and reality therapy for 8 weeks at the end of in the first stage, second stage and the third stage. The efficacy was assessed by the Yale-Brown Obsessive Compulsive Scale （Y-BOCS） before treatment,8 weeks, 16 weeks, and 24 weeks after treatment,respectively. Results The total score of the YBOCS before the treatment and at the 24th week after treatment was （21.10 ±4.69） and （ 10.18 ±6. 14）. According to the score-reducing rate of the YBOCS , recovery rate was 34. 0%, effective rate was 42.0%. Conclusion Sequential psychotherapy combined with SSRIs is an effective treatment for refractory OCD.

关 键 词：序贯心理治疗 选择性5羟色胺再吸收抑制剂 难治性强迫症 

分 类 号：R749.7[医药卫生—神经病学与精神病学]