2型糖尿病伴牙周炎患者糖化血红蛋白与肿瘤坏死因子α水平的相关性分析  

Correlation Analysis between Glycosylated Hemoglobin and Level of TNF-α in Patients with Type 2 Diabetes Mellitus and Periodontitis

作　　者：王丹[1] 周晓佳[1] 刘冰阳[2] 刘洪利[1] 林晓萍[1] 

机构地区：[1]中国医科大学附属盛京医院口腔科,沈阳110004 [2]中国医科大学第93期临床医学7年制,沈阳110001

出　　处：《中国医科大学学报》2010年第12期1024-1027,共4页Journal of China Medical University

基　　金：辽宁省自然科学基金资助项目(20092139)

摘　　要：目的探讨患有牙周炎与非牙周炎的2型糖尿病患者血清、龈沟液肿瘤坏死因子α(TNF-α)水平及其与糖化血红蛋白(HbA1c)是否具有相关性。方法 ELISA法测定84例2型糖尿病患者血清、龈沟液中的TNF-α含量,同时测定2型糖尿病患者的糖化血红蛋白水平并根据糖化血红蛋白含量和牙周状况分组。结果对照组1和实验组1各项牙周指标均有统计学差异(P<0.05);对照组2和实验组2各项牙周指标差异显著(P<0.05),血清TNF-α和龈沟液TNF-α之间有统计学意义;实验组2血清TNF-α含量显著高于实验组1,差异显著(P<0.05);且实验组2糖化血红蛋白(HbA1c)水平与龈沟液和血清中TNF-α含量具有正相关性(r分别为0.516、0.492,P<0.05)。结论对糖尿病患者除了控制HbA1c水平,还应做好牙周病的健康教育和牙周维护,可有效地减少牙周炎的发生或减轻牙周炎症。降低糖尿病患者牙周感染的机率和加强牙周维护,也可有效地控制HbA1c水平,缓解糖尿病的糖代谢状况。Objective To investigate the levels of tumor necrosis factor α（TNF-α）in serum and gingival crevicular fluid（GCF）from periodontitis and non-periodontitis patients with type 2 diabetes mellitus.And analyze the relationship between the levels and glycosylated hemoglobin.Methods To determine the concentrations of TNF-α in serum and gingival crevicular fluid from 84 patients with type 2 diabetes mellitus by enzyme linked immunosorbent assay（ELISA）method.At the same time,determine the levels of glycosylated hemoglobin from type 2 diabetic.Grouped according to glycated hemoglobin and periodontal status.Results The various periodontal indicators are remarkable differences in control group 1 and experimental group 1（P 〈 0.05）;The various clinical indicators are significant differences in control group 2 and experimental group 2（P 〈 0.05）,levels of TNF-α in serum and in gingival crevicular fluid showed significantly difference;Concentration of TNF-α in serum in experimental group 2 significant higher than that in experimental group 1,significant difference（P 〈 0.05）;In experimental group 2,between the level of glycosylated hemoglobin and the concentrations of TNF-a in serum and gingival crevicular fluid were positive correlation（correlation coefficient r is 0.516,0.492,P 〈 0.05）,respectively.Conclusion In addition to control HbA1c levels in patients with diabetes,we should do a good job of periodontal health education and periodontal maintenance that could effectively reduce the incidence of periodontitis or reduce periodontal inflammation.In turn,to reduce the risk of periodontal infection and enhance periodontal maintenance in diabetic can also control HbA1c levels effectively,and ease the metabolic condition of diabetes mellitus.

关 键 词：2型糖尿病 牙周炎 肿瘤坏死因子Α 龈沟液 糖化血红蛋白 

分 类 号：R781.4[医药卫生—口腔医学]