^(235)U、^(147)Pm、^(153)Sm单独及混合照射时对骨肉瘤细胞的增殖抑制作用  

INHIBITION OF PROLIFERATION IN BONE TUMOR CELLS AFTER IRRADIATION BY 235 U, 147 Pm, 153 Sm

作　　者：朱寿彭[1] 肖东[1] 韩晓枫[1] 

机构地区：[1]苏州医学院,215007

出　　处：《辐射防护》1999年第6期449-451,共3页Radiation Protection

摘　　要：本研究运用四氮唑（ＭＴＴ） 显色反应，观察了２３５Ｕ、１４７Ｐｍ 、１５３Ｓｍ 单独及混合照射骨肉瘤细胞时，对瘤细胞增殖抑制作用的程度比较。结果表明，各核素单独照射（照射用放射性活度为：２３５Ｕ，１２８４Ｂｑ；１４７Ｐｍ ，７．４×１０５ Ｂｑ；１５３Ｓｍ ，７．４×１０５ Ｂｑ）及混合照射（２３５Ｕ＋ １４７Ｐｍ ，２３５Ｕ＋ １５３Ｓｍ ，１４７Ｐｍ ＋ １５３Ｓｍ ，其放射性活度均为各自单独照射时的一半） 时，在受照１２ 及２４ ｈ 阶段，均对骨肉瘤细胞有明显的增殖抑制作用。In this paper, inhibition of proliferation in bone tumor cells after simple or mixed irradiation by 235 U, 147 Pm, 153 Sm was studied. Experimental results indicated that proliferation of bone tumor cells was significantly inhibited at 12 h^24 h after a simple irradiation by 235 U (128.4 Bq) , 147 Pm (7.4×10 5 Bq), and 153 Sm(7.4×10 5 Bq) as well as mixed irradiation by 235 U + 147 Pm (64.2 Bq+3.7×10 5 Bq), 235 U+ 153 Sm(64.2 Bq+3.7×10 5 Bq), 147 Pm+ 153 Sm (3.7 ×10 5 Bq+3.7×10 5 Bq). The findings show that the inhibition rate with mixed irradiation was more than that with simple irradiation $$$$(

关 键 词：铀235照射 骨肉瘤细胞 增殖抑制 钷147 钐153 

分 类 号：R738[医药卫生—肿瘤] R730.231.2[医药卫生—临床医学]