脑梗塞患者血浆纤维结合蛋白变化及分析  

The Variation and Analysis of Plasma Fibronectin with Cerebral Infarction Patients

作　　者：包雪鹦[1] 由阳[1] 金海燕[1] 于挺敏[2] 

机构地区：[1]解放军第208医院神经内科,吉林长春130062 [2]吉林大学第二临床医院神经内科,吉林长春130021

出　　处：《深圳中西医结合杂志》2010年第6期361-363,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨发病后不同时间及不同梗塞面积的脑梗塞患者血浆纤维结合蛋白的变化及其临床意义。方法:选择脑梗塞患者493例,健康体检者349例,应用日立7600-020全自动生化分析仪检测清晨空腹状态下血浆纤维结合蛋白(Fn),并按脑梗塞发病时间及梗塞面积不同进一步分组,与对照组进行比较。结果:脑梗塞发病后患者血浆Fn在48h内已升高,之后逐渐降低,但至14d后仍高于正常水平。脑梗塞面积越大,血浆Fn升高越显著。结论:血浆Fn变化与脑梗塞病情密切相关,血浆Fn可作为脑梗塞治疗时主要监测指标之一。Objective To explore the variation regularity and clinical significance of plasma fibronectin in cerebral infarction（CI） patients at different periods after onset and with different infarct sizes.Methods Plasma fibronectin （pFn） of 493 patients with CI were determined by Hitachi 7 600-020 holo-automatic biochemistry analyzer,divided by different periods after onset and infarct sizes with CI patients,and then compared to those of 349 healthy people.Results Plasma fibronectin ascend in 48h after onset,then descend gradually,but are still higher than normal level after onset 14d;The plasma fibronectin were ascebded more significant in the larger infarct size.Conclusion The variation of plasm fibronectin should be closely related to pathogenetic condition of the CI patients,which can be one of the main monitoring predictors on treatment of CL.

关 键 词：脑梗塞 血浆纤维蛋白 血液流变学 炎症 

分 类 号：R743.33[医药卫生—神经病学与精神病学]