同步放化疗治疗中晚期宫颈癌的临床疗效观察  

The Clinical Observation of Low Dose Docetaxal and DDP United the Radiotherapy and Chemotherapy in the Advanced Cancer of Cervic

作　　者：沈李伟[1] 翟爱民[1] 杜利力[1] 邱文生[1] 

机构地区：[1]青岛大学医学院附属医院,青岛266003

出　　处：《中国医药导刊》2010年第11期1877-1877,1879,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨观察中晚期宫颈癌同步放化疗的临床疗效和毒副作用。方法:49例经病理确诊的Ⅱb～Ⅳ期宫颈癌患者,随机分为同步放化疗组26例和单纯放疗组23例,两组同样放疗剂量,同步放化疗组给予TC方案(多西紫杉醇、顺铂)化疗3～4个疗程,每周1次。比较两组的治疗效果和不良反应。结果:同步放化疗组有效率91.8%,3年生存率83.3%,单纯放疗组有效率71.4%,3年生存率52.4%,两组差异有统计学意义(P<0.05),不良毒副作用发生率差异无统计学意义(P>0,05),以0～Ⅱ度为主。结论:同步放化疗治疗中、晚期宫颈癌可显著提高有效率和生存率,毒副作用两组无明显差异。Objective： To observe the reaction and the adverse reaction of low dose docetaxal and DDP unite the radiotherapy and chemotherapy in the advanced cancer of cervic.Methods：Separated the 49 Ⅱb-Ⅳ stage cervic cancer cases denifited by pathology to 26 cases received the radiotherapy and chemotherapy and the 23 cases receivde only radiotherapy, received the same radiotherapy dose,the 26 cases received the radiotherapy and chemotherapy received 3-4 cycle of low dose docetaxal and DDP.intervaled 1 week.Compared the thempetic efficacy and the adverse effect. Results： The efficacy of the radiotherapy and chemotherapy was 91.8% compared the only radiotherapy was 71.4%, of the radiotherapy and chemotherapy was 83.3% compared the only radiotherapy was 52.4%（P〈0.05）, the adverse effect almost the same（P〉0.05）. The adverse effect was tolerance and intertible through the treatment. Conclusion：The radiotherapy and chemotherapy could raise the therapetic efficacy and the survival rate in the advanced cancer of cervic,and the adverse effectalmost the same with the only radiotherapy.

关 键 词：同步放化疗 宫颈癌 多西紫杉醇 顺铂 

分 类 号：R737.33[医药卫生—肿瘤]