多西他赛联合卡培他滨治疗老年进展期胃癌疗效观察  

The Effectivness of Compound Injection of Docetaxel Combined with Capecitabine on Aged Patients in Advanced Gastric Cancer

作　　者：陈苏蓉 陈苏娟 陈平 周成英 宋俊标 刘红旗 严必中 

机构地区：[1]盐城市第一人民医院肿瘤科,盐城224001

出　　处：《中国医药导刊》2010年第11期1925-1925,1927,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:观察多西他赛联合卡培他滨治疗老年进展期胃癌的临床疗效及毒副反应。方法:40例老年Ⅲ～Ⅳ期胃癌患者以多西他赛联合卡培他滨或奥沙利铂联合亚叶酸钙、氟脲嘧啶的方案化疗,均化疗2个周期以上。每个周期28天。结果:多西他赛联合卡培他滨方案的有效率(CR+PR)为58.8%,有末梢神经炎、手足综合征、血液学毒性,胃肠道反应为23.5%。奥沙利铂联合亚叶酸钙、氟脲嘧啶方案的有效率(CR+PR)为47.8%,有末梢神经炎、血液学毒性,胃肠道反应为43.5%。结论:多西他赛联合卡培他滨治疗老年进展期胃癌副反应小,疗效确切。Objective： To evaluate the curative effect and side effect of compound injection of Docetaxel combined with Capecitabine in treating aged patients who suffered from advanced gastric cancer. Methods：40 cases, with gastric cancer staged Ⅲ-Ⅳ,were divided into two groups.The test group was treated with Docctaxel combined with Capecitabine for more than two cycles.The control group was treated with 5-Fluorouracil combined with Leucovorin and Oxaliplatin for more than two cycles.The chemotherapy interval was 28days.Results： The curative effect（CR＋PR） of the test group were 58.8%.The side effect included nerve toxication,bone marrow suppression,gastrointestinal reaction were 23.5%. The curative effect（CR＋PR） of the control group were 47.8%.The side effect included nerve toxication,bone marrow suppression,gastrointestinal reaction were 43.5%.Conclusions：The compound injection of Docetaxel combined with Capecitabine is effective for aged patients who suffered from advanced gastric cancer and its side effect is mild.

关 键 词：多西他赛 卡培他滨 联合化疗 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]