脑血康分散片处方工艺研究  

Study on Formulation of Naoxuekang Dispersible Tablets

作　　者：符美燕[1] 吕竹芬[1] 陈燕忠[1] 谢清春[1] 申楼[1] 

机构地区：[1]广东省药物新剂型重点实验室/广东药学院药物研究所,广东广州510006

出　　处：《中药材》2010年第11期1800-1803,共4页Journal of Chinese Medicinal Materials

基　　金：广东省科技计划项目(2007B031405003)

摘　　要：目的:考察及筛选脑血康分散片的最佳处方和确定制备工艺。方法:经过前处理水蛭浸膏和系列试验筛选填充剂、崩解剂等辅料,通过内外加入崩解剂法,确定处方和制备工艺。结果:该制剂确定了以微晶纤维素为填充剂,以交联羧甲基纤维素钠、低取代羟丙基纤维素作为崩解剂的分散片处方。该制剂的平均崩解时限为52 s,含氮量为5.47 mg/片,分散均匀性、重量差异及微生物限度均符合规定。结论:研制的脑血康分散片处方合理、工艺可行,符合分散片的质量要求。Objective：To study the formulation of Naoxuekang dispersible tablets.Methods：The formulation was determined by pre-processing leech extractum prior to a series of experiments used to screen excipients like bulking agents and disintegrants and so on,and by adding disintegrants within and without.Results：Microcrystalline cellulose was determined as the bulking agent,and carboxymethyl cellulose and low-substituted hydroxypropyl cellulose were determined as the disintegrants of Naoxuekang dispersible tablet formula.The average disintegration time and nitrogen content of one tablet were 52 seconds and 5.47 milligrams,respectively.Also disperse homogeneity,weight variation and microbial limit all met the requirements in Ch.P.Conclusion：The prepared Naoxuekang dispersible tablet is reasonable in formula,feasible in technology,which meets the quality standards.

关 键 词：脑血康分散片 水蛭 处方工艺 

分 类 号：R943[医药卫生—药剂学]