利培酮口腔崩解片治疗难治性精神分裂症的对照观察  

A Comparative Study of Risperidone Orally Disintegrating Tablets and Clozapine in the Treatment of Refractory Schizophrenia

作　　者：张淑芳 马闯胜 

机构地区：[1]河南省郑州市第八人民医院心理科,郑州450006

出　　处：《中国医药导刊》2010年第12期2095-2096,共2页Chinese Journal of Medicinal Guide

摘　　要：目的：比较利培酮口腔崩解片与氯氮平治疗难治性精神分裂症的疗效和不良反应.方法：将符合研究条件的难治性精神分裂症患者随机分成研究组和对照组,分别给予利培酮口腔崩解片和氯氮平治疗,应用阳性和阴性症状量表（PANSS）和副反应量表（TESS）评定疗效和不良反应,分别在治疗前和治疗的2、4、8、12周末各评定一次.结果：治疗中脱落5例.治疗12周后两组PANSS评分与治疗前比较明显减少（P＜0.01）,各期组间比较无显著统计学差异（P＞0.05）.研究组有效率为37.50%,对照组为43.33%,二者无明显差别（P＞0.05）.研究组的不良反应发生率为18.75%,明显低于对照组（53.33%,χ2=8.09,P＜0.01）.结论：利培酮口腔崩解片治疗难治性精神分裂症的疗效与氯氮平相当,不良反应更小,可作为首选药物.Objective：To explore the curative effect and side effects of risperidone orally disintegrating tablets and clozapine in the treatment of refractory schizophrenia.Methods：67 refractory schizophrenics were randomly assigned into study group and control group,treated with risperidone orally disintegrating tablets and clozapine for 12 weeks.The curative effect and side effects were evaluated with Positive and Negative Symptoms Scale （PANSS） and Treatment Emergent Symptom Scale （TESS） before the treatment and after 2. 4. 8. 12 weeks. Results：5 patients were missing.After 12 weeks treatment,the scores of PANSS were reduced significantly than before treatment in two groups （P〈0.01）,there were no significant difference between two groups at same time （P〉0.05）.The effective rate of study group and control group were 37.50% and 43.33%,there were no significant difference （χ2=0.22,P〉0.05）.The rate of side effect of study group was 18.75%,it was significantly lower than control group （53.33%,χ2=8.09,P〈0.01）.Conclusion：Risperidone orally disintegrating tablets has better curative effect like clozapine in the treatment of refractory schizophrenia with low side effect,it could be first-selected drug.

关 键 词：利培酮口腔崩解片 氯氮平 难治性精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]