低剂量5-FU静脉泵持续点滴联合艾迪注射液治疗晚期胃癌  

Low dose of 5-FU continuous infusion by syringe driver with Traditional Chinese medicine-Ai-Di parenteral solution for the advanced gastric cancer

作　　者：文旭[1] 顾荣民[1] 李刚[1] 明学志[1] 陈环球[1] 

机构地区：[1]江苏省肿瘤防治研究所暨医院胃癌中心,江苏南京210009

出　　处：《现代医学》2010年第6期597-600,共4页Modern Medical Journal

基　　金：江苏省科技厅社会发展重大项目资助(BS2007010)

摘　　要：目的:评价低剂量5-FU静脉泵持续点滴联合艾迪注射液治疗晚期胃癌的客观疗效及毒副反应。方法:将56例Ⅳ期胃癌患者随机分成艾迪组(n=27)和对照组(n=29)。艾迪组采用5-FU静脉泵持续点滴,同时联合中药艾迪注射液治疗;对照组仅采用5-FU静脉泵持续点滴治疗。结果:艾迪组总有效率为59.3%(16/27),进展(PD)率7.4%(2/27);对照组总有效率为51.7%(15/29),PD率34.5%(10/29)。毒副反应主要为口腔炎艾迪组29.6%(8/27)、对照组55.2%(16/29),艾迪组低于对照组(P<0.05)。腹泻艾迪组29.6%(8/27)、对照组51.7%(15/29),艾迪组低于对照组(P<0.05)。结论:艾迪注射液联合低剂量5-FU长疗程持续静滴疗效好,毒副反应不严重,值得进一步研究。Objective： To evaluate the objective anti-tumor efficacy and safety of low dose of 5-FU continuous infusion（ci） for a long time by syringe driver with traditional Chinese medicine-Ai-Di parenteral solution for the advanced gastric cancer.Methods： 56cases of advanced gastric cancer were divided into two groups.The cases of Ai-Di group used low dose of 5-FU ci by syringe driver with traditional Chinese medicine-Ai-Di parenteral solution.The cases of control group only used 5-FU ci by syringe driver.Results： Ai-Di group： 59.3%（16/27）of response rate were achieved with PD 7.4%（2/27）,in all 27 cases;Control group： 51.7%（15/29） of response rate were achieved with PD 34.5%（10/29） in all 29 cases.The major toxicity included mucositis,diarrhea,phlebitis,nausea,vomit,neutropenia.Among side effects mucositis was the most commonly seen.Most were grade Ⅰ-Ⅱwhich were tolerable for all patients.The side effects of mucositis and diarrhea in Ai-Di group were less than that in control group.Conclusion： The regimen with traditional Chinese medicine-Ai-Di parenteral solution was an effective chemotherapy for advanced gastric cancer.The adverse reactions were not severe.Further clinical study should be warranted.

关 键 词：胃肿瘤 氟尿嘧啶 持续静脉点滴 化学疗法 中药艾迪注射液 

分 类 号：R735.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]