CYP2E1基因多态性与宣威肺癌易感性的病例对照研究  

Study on the Relationship between Genetic Polymorphism of Human Cytochrome P450 2E1 Gene and Susceptibility to Xuanwei^s Lung Cancer

作　　者：刘华[1] 苏艳丹[1] 陈瑞春[1] 卫俊杰 

机构地区：[1]昆明医学院第一附属医院检验科,昆明650032 [2]云南省中医院检验科,昆明650021

出　　处：《现代检验医学杂志》2010年第6期23-26,共4页Journal of Modern Laboratory Medicine

摘　　要：目的 探讨宣威地区CYP2E1基因多态性与肺癌易感性的关系.方法 采用聚合酶链式反应（PCR） 和限制性片段长度多态性（RFLP） 技术检测108例宣威肺癌患者和108例对照的RsaI识别的CYP 2E1基因型CYP2E1的基因多态性.结果 此次研究结果为CYP 2E1基因型频率在肺癌组和对照组的分布差异无统计学显著性意义（χ2=1.571,P＞0.05）;烧烟煤者发生肺癌的危险性升高（OR=2.473,P＜0.05）,CYP 2E1C1/C1基因型且烧烟煤者患肺癌的风险明显增高（OR=3.492,P＜0.05）;饮酒与肺癌风险有较强的联系（OR=3.654,P＜0.05）,CYP2E1C1/C1基因型且饮酒者患肺癌的风险明显增高（OR=5.7,P＜0.05） .结论 CYP 2E1基因多态性与肺癌无明显相关性,但与烧烟煤及饮酒有联合作用.Objective To evaluate the relationship between genetic polymorphism of human Cytochrome P450 2El （CYP） Gene polymorphism and lung cancer susceptibility among Xuanwei in China. Methods The genotype frequencies of RsaI restriction fragment length polymorphism were analyzed for 108 lung cancer cases and 108 cases of normal control among Xuanwei in China. Results No significant difference of CYP 2El was observed between lung cancer cases and normal controis （Zz= 1. 571 ,P〉0. 05）;Using bituminous coal was strongly associated with the risk of lung cancer （OR = 2. 473 ,P〈 0. 05）. Persons using bituminous coal with the CYP 2E1C1/C1 geno-type had an odds ratio of lung cancer（OR= 3. 492,P d0. 05）;drinking was strongly associated with the risk of lung cancer （OR= 3. 654,P〈0.05）,Persons drinking with the CYP 2E1C1/C1 genotype had an odds ratio of lung cancer （OR=5.7,P^O. 05）. Conclusion There was no significant relationship between cytochrome CYP 2El genetic polymorphism and lung cancer. There may be relationship between the CYP 2El polymorphism combined using bituminous coal and drinking and lung cancer.

关 键 词：肺肿瘤 细胞色素P450 基因多态性 易感性 

分 类 号：R734.2[医药卫生—肿瘤] Q786[医药卫生—临床医学]