副猪嗜血杆菌主要毒力因子和致病机理的研究进展  

Study Progress on Major Virulence Factors and Pathogenic Mechanism of Haemophilus Parasuis

作　　者：李静怡[1] 张建民[1] 徐成刚[1] 郭莉莉[1] 陈济铛[1] 廖明[1] 

机构地区：[1]华南农业大学兽医学院农业部动物疫病防控重点开放实验室,广州510642

出　　处：《中国畜牧兽医》2010年第12期173-176,共4页China Animal Husbandry & Veterinary Medicine

摘　　要：副猪嗜血杆菌病又称革拉斯氏病(Glasser’s disease),引起猪的多发性浆膜炎、关节炎和脑膜脑炎,是近年来严重危害养猪业的细菌性传染病,呈世界性分布,并已证实在中国绝大多数猪场存在和流行。副猪嗜血杆菌的血清型众多,不同血清型的副猪嗜血杆菌毒力差异很大,对其毒力因子了解很少,对其主要的致病机理更是知之甚少,现已发现该病原可能的毒力相关因子有荚膜、菌毛、脂多糖、外膜蛋白及酶类等。笔者对这些毒力因子及该病的致病机理进行综述,以期为该病的防控提供科学依据。Haemophilus parasuis disease is known as leather Las disease（Glasser＇s disease）,which is a bacterial pig disease,causing pigs serositis,arthritis and meningoencephalitis.Recent years,it shows a worldwide distribution and the existence in most farmsand of China has been confirmed,bringing serious damages to swine industry.There are many serotypes of Haemophilus parasuis,virulences of different serotypes are not same,people know very little of its virulence factors,and less of the pathogenic mechanism,the pathogenic potential virulence factors associated with capsule,pili,lipopolysaccharide,outer membrane proteins,enzymes and so on.In this paper,these virulence factors and pathogenesis of the disease were reviewed in order to provide the scientific basis for prevention and control of the disease.

关 键 词：副猪嗜血杆菌 毒力因子 致病机理 

分 类 号：S852.612[农业科学—基础兽医学]