左氧氟沙星、雷贝拉唑和呋喃唑酮三联方案治疗幽门螺杆菌  

Study of the Efficacy of Raberprazole Combined with Levofloxacin and Furazolidon in the Treatment of Helicobacter Intection

作　　者：傅长来[1] 魏金文[2] 蒋丹斌[1] 蔡霞[1] 沈秀萍[1] 孙剑珊[1] 仇玉平[1] 唐光华[1] 

机构地区：[1]江苏省盐城市第三人民医院消化科,江苏盐城224000 [2]江苏大学附属医院消化科,江苏镇江212001

出　　处：《中国临床医学》2010年第6期851-852,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:观察雷贝拉唑联合左氧氟沙星、呋喃唑酮根除幽门螺杆菌(Hp)的临床疗效。方法:选择胃镜检查Hp阳性的慢性胃炎及消化性溃疡患者86例,随机分成治疗组和对照组。治疗组给予雷贝拉唑肠溶片10mg,均为2次.d-1;左氧氟沙星0.2g,每天2次;呋喃唑酮0.1g,每天2次,疗程1周;对照组给雷贝拉唑10mg,阿莫西林1.0g,甲硝唑0.4g,均为2次.d-1,疗程1周。疗程结束4周后复查Hp,根除率治疗组为84.8%,对照组为75.0%,两者有显著差异。结论:雷贝拉唑联合左氧氟沙星及呋喃唑酮三联根治幽门螺杆菌具有疗效好、不良反应小、价格便宜的特点,可作为根除幽门螺杆菌的治疗方案之一,值得推广。Objective：The aim of this study was to test the efficacy of Raberprazole combines Levofloxacin and Furazolidone for the treatment for Helicobacter pylori infection.Methods： Eighty-six H.pylori-positive patients（contain chronic gastritic and peptic ulcer） were randomized divided into therapy group and control group： Rabeprazole 10 mg bid ＋Levofloxacin 0.2g bid（therapy group）/ Amoxicillin 1.0g bid（control group）＋Furazolidone 0.1g bid（therapy group）/Metronidizone 0.4g bid（control group） for 1 week.H.pylori was retested four weeks later.Results： The eradication rates of two regimen were： therapy group was 84.8%;control group was 75.0%.The eradication rates of H.pylori of the two groups were significant different（P0.05）.Conclusions： Raberprazole＋levofloxacin＋furazolidone triple therapy for H.Pylori infection is effective、cheap and smaller side effect,it is worthy to be extended as one of the threatments for Helicobacter pylori infection.

关 键 词：幽门螺杆菌 左氧氟沙星 雷贝拉唑 

分 类 号：R573[医药卫生—消化系统]