Alzheimer病、血管性痴呆和健康老年人神经心理学与脑血流灌注的相关性研究  

Neuropsychology andits correlation with cerebralbloodflow in patients with Alzheimer’s disease,vascu lar dementia and normalsineors

作　　者：昂秋青[1] 江开达[1] 黄延炎 张明园[3] 赵晋华[2] 林祥通[2] 贺凤凤[2] 顾牛范[1] 

机构地区：[1]上海医科大学精神医学教研室,200030 [2]上海医科大学附属华山医院 [3]上海市精神卫生中心

出　　处：《中华核医学杂志》1999年第4期193-196,共4页Chinese Journal of Nuclear Medicine

摘　　要：目的　研究Ａｌｚｈｅｉｍｅｒ 病（ＡＤ） 、血管性痴呆（ＶＤ） 和健康老年人（ＮＡ） 的神经心理学和功能性影像学特征及两者的相关性。方法　对３６ 例ＡＤ、３５ 例ＶＤ 患者和３７ 名ＮＡ 进行神经心理学评定和脑血流灌注显像。结果　ＡＤ 和ＶＤ 患者各量表成绩显著低于ＮＡ，ＡＤ 的物品记忆测验成绩（ＦＯＭ）显著低于ＶＤ。ＡＤ 和ＶＤ患者大部分脑区放射性计数比值（ＲＡＲ）明显低于ＮＡ，ＡＤ右顶叶和双额叶的ＲＡＲ明显低于ＶＤ。ＮＡ的ＦＯＭ 与多个脑区的ＲＡＲ 相关，ＡＤ 多项量表成绩与右顶叶ＲＡＲ相关，ＶＤ多项量表成绩与左顶叶ＲＡＲ相关。结论　左、右顶叶血流灌注下降分别对ＶＤ 和ＡＤ 的认知缺损有较大影响，提示ＶＤ 和ＡＤ分别具有不同的左。Objective To study the psychological,functionalimaging findings and the relationship be tweenthem in patients with Alzheimer’s disease (AD),vascular dementia (VD) and normal sineors (NS)- Methods Psychologicalevaluation withratingscalesandfunctionalimagingexamination withsingle photonemis sion computedtomography were conductedto AD,VD (both metthe DSM Ⅳdiagnostic criteria) and NS- Re sults In psychologicalexamination,ADand VDshowedsignificantlylowerscoresin everyscalethan NS,andin Fuld goods memorytest(FOM) ,ADappeared even worsethan VD- Infunctionalimaging examination,at most brain areas,radioactiveratio (RAR)in ADand VDwere obviouslylowerthanthatin NS- Whileinrightparietal lobe and bilateralfrontallobes,RARin ADshowedsignificantlylowerthanin VD- FOMscoreof NSwascorrelat ed with RARin severalbrain areas- RARsofrigntparietallobein ADand ofleftparietallobein VDshowedcor relation with scores of mostrating scales- Conclusions Hypoperfusion in right parietallobe of ADand in left parietallobe of VDcontributes mainlytotheircognitive deficiency,this mayfurthersuggestthe differentrightor lefthemisphere mechanism in ADand VD-

关 键 词：早老性痴呆 血管性痴呆 神经心理学 肺血流灌注 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R816.1[医药卫生—临床医学]