蝙蝠葛诺林碱对小鼠软脑膜微循环障碍的改善作用  

Effects of Daurinoline on Microcirculation of Cerebral Pia Mater in Mice

作　　者：张晋 杨磊[2] 郭莲军[3] 

机构地区：[1]湖北省中山医院神经内科,湖北武汉430033 [2]华中科技大学同济医学院附属协和医院麻醉科,湖北武汉430022 [3]华中科技大学同济医学院基础医学院药理学系,湖北武汉430030

出　　处：《武汉大学学报（医学版）》2011年第1期36-39,共4页Medical Journal of Wuhan University

摘　　要：目的:探讨蝙蝠葛诺林碱对小鼠软脑膜微循环障碍的改善作用。方法:制备开放式颅窗,采用BI2000图像分析系统监测小鼠软脑膜微循环,并在软脑膜局部滴加去甲肾上腺素复制微循环障碍模型,观察局部给予蝙蝠葛诺林碱对小鼠软脑膜微小血管管径和开放数目的影响。结果:不同剂量的蝙蝠葛诺林碱对去甲肾上腺素所致的软脑膜微动脉和微静脉收缩均有明显的扩张作用,对去甲肾上腺素所致的软脑膜微小动脉和微小静脉血管开放数目减少有明显的逆转作用,与生理盐水组相比有显著性差异(P<0.05或P<0.01)。结论:蝙蝠葛诺林碱能扩张小鼠软脑膜微小血管管径,增加微小血管开放数目,改善小鼠软脑膜微循环。Objective： To investigate the effect of daurinoline on cerebral pia mater microcirculation in mice. Methods： An open cranial window was performed and microcirculation disturbance state was established by means of administering noradrenaline on the cerebral pia mater. The effect of daurinoline was observed from the changes of the diameters and numbers of the arterioles and venules. Results： Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline. Conclusion： It suggests that daurinoline would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury.

关 键 词：蝙蝠葛诺林碱 软脑膜微循环 小鼠 

分 类 号：R743[医药卫生—神经病学与精神病学]