福赛斯坦纳菌在2型糖尿病患者龈下菌斑中的分布  

Prevalence of Tannerella forsythensis in subgingival plaque of type 2 diabetic patients

作　　者：马丽[1] 张建全[2] 潘亚萍[1,3] 

机构地区：[1]中国医科大学口腔医学院口腔生物学教研室,沈阳110002 [2]天津市宝坻区人民医院口腔科,天津301800 [3]中国医科大学口腔医院牙周科,沈阳110002

出　　处：《华西口腔医学杂志》2011年第1期57-61,共5页West China Journal of Stomatology

基　　金：国家"十一五"科技支撑计划基金资助项目(2007-BAI-18B02);辽宁省科学技术计划基金资助项目(2007225007)

摘　　要：目的观察福赛斯坦纳菌(T.forsythensis)在2型糖尿病患者不同牙周状况下的分布及其与相关影响因素的关系,探讨T.forsythensis在慢性牙周炎与2型糖尿病中的作用。方法采集160例不同牙周状况的2型糖尿病患者的龈下集合菌斑,采用酚-氯仿法提取细菌DNA,应用聚合酶链反应法对T.forsythensis进行检测。采用Pearson相关和Logistic回归等统计方法分析T.forsythensis与牙周及全身状况的相关性。结果 160例糖尿病患者中,T.forsythensis在牙周健康组未检出,在轻度牙周炎组检出率为47.82%,中度牙周炎组为48.71%,重度牙周炎组为67.39%。重度牙周炎组的检出率明显高于轻、中度组(P<0.05)。与T.forsythensis独立相关的因素有简化口腔卫生指数和糖尿病病程,OR值分别为1.947、0.873。结论 T.forsythensis在2型糖尿病牙周炎患者中的分布与口腔卫生状况、牙周破坏程度及糖尿病病程有关。Objective To study the prevalence of Tannerella forsythensis（T.forsythensis） in the subgingival plaque of type 2 diabetes,analyze the relationship between T.forsythensis and related factors,discuss the role of T.forsythensis in the chronic periodontitis and type 2 diabetes.Methods 160 subgingival plaque samples were collected from type 2 diabetic patients and pathogens genomic DNA were extracted by phenol and chloroform from plaque.T.forsythensis was detected by polymerase chain reaction,and Pearson correlation and Logistic regression analysis were used to analyze the relationship between T.forsythensis and systemic factors and periodontal status.Results The prevalence of T.forsythensis in mild,moderate,severe periodontitis group was 47.82%,48.71%,67.39% respectively,and the prevalence was higher in the severe periodontitis group than in mild,moderate group（P0.05）.There was no T.forsythensis in 6 diabetic patients with healthy periodontium.Logistic regression analysis illustrated that the prevalence of T.forsythensis was associated with simplified oral hygiene index（OHI-S） and diabetic duration（OR=1.947,OR=0.873）.Conclusion The prevalence of T.forsythensis in type 2 diabetes with chronic periodontitis was related with oral hygiene,periodontal status and diabetic duration.

关 键 词：2型糖尿病 慢性牙周炎 福赛斯坦纳菌 

分 类 号：R781.4[医药卫生—口腔医学]