新诊断青少年肌阵挛性癫痫患者的认知功能研究  

Study on the Cognitive Function in the Newly Diagnosed Juvenile Myoclonic Epilepsy

作　　者：王天成[1] 王为民[1] 罗福民[1] 叶江[1] 赵莉[1] 

机构地区：[1]兰州大学第二医院神经内科,甘肃省兰州市730030

出　　处：《中国全科医学》2010年第36期4077-4079,共3页Chinese General Practice

摘　　要：目的研究新诊断青少年肌阵挛性癫痫(juvenile myoclonic epilepsy,JME)患者的认知功能,评价影响其认知功能的主要因素。方法通过5项神经心理学测试(包括中文听觉词汇回忆测验、词汇流畅性测验、连线测验、Stroop字色干扰测验、数字广度测验)、2项情绪测验(焦虑自评量表和抑郁自评量表)和1项智能测验(简易智力状态量表)后,比较22例新诊断JME患者(JME组)和22例健康自愿者(对照组)的认知功能,同时进行相关危险因素分析(包括年龄、性别、家族史、文化程度、发病年龄、发作频率、脑电图异常情况和病程)。结果 JME组患者的听觉词汇回忆测验中短时延迟回忆、长时延迟回忆和再认回忆(P<0.01),连线测验A型连线时间(P<0.01)和B型连线时间(P<0.01),词汇流畅性测验的词汇总数(P<0.01),Stroop字色干扰试验的读字时间和读色时间(P<0.01),数字广度测验的顺背数及倒背数(P<0.01),与对照组比较,差异均有统计学意义;而JME组患者的智力测验和情绪测验结果与对照组比较差异无统计学意义(P>0.05)。危险因素相关分析表明:发病年龄与词汇的记忆有密切关系(P<0.05)。结论新诊断JME患者可能在记忆功能、注意力和额叶认知功能方面有不同程度的障碍。Objective To study the cognitive function in newly diagnosed juvenile myoclonic epilepsy and estimate the affecting factors to the cognitive function.Methods 22 newly diagnosed patients with juvenile myoclonic epilepsy and 22 healthy volunteers were tested by 5 neuropsychological tests（Auditory verbal memory test,Verbal fluency test,Trail making test,the Stroop test,Digit span test）,two emotional tests（self-rating anxiety scale（SAS）,self-rating depression scale（SDS）） and one intelligence test（mini-mental state examination,MMSE） to examined the relation between the scores of neuropsychological tests and the risk factors by using Pearson′s correlation test.Results Compared with healthy volunteers,the newly diagnosed patients with juvenile myoclonic epilepsy exhibited worse performances in the immediately and delayed recall（P〈0.01）,recognition task（P〈0.01）,verbal fluency（P〈0.01）,time of reading words and color in the Stroop-test（P〈0.01）,forward and backward digit spans（P〈0.01）.The scores of the MMSE test,SAS and SDS did not differ significantly between the two groups（P〉0.05）.There were significant correlations between verbal memory and onset age.When compared with the newly diagnosed patients（t=0.450,P〈0.05）.The patients with intricate epileptic form showed lower score in the immediately and delayed recall of auditory verbal learning test（P〈0.05）,there were no statistical differences in the attention and executive function.Conclusion The newly diagnosed patients with juvenile myoclonic epilepsy may exhibit impaired cognitive function in terms of memory,attention and execution,while having normal intelligence and mood.

关 键 词：肌阵挛性癫痫 幼年型 认知功能 神经心理学测验 

分 类 号：R742[医药卫生—神经病学与精神病学]