中线恶性网织细胞增生症的病理及免疫表型研究  

Clinic opatholgic and immunophenotypic studies on midline malignant histiocytosis

作　　者：嵇宪生[1] 邱建华[2] 黄维国 姜鸿彦[2] 乔莉[2] 

机构地区：[1]解放军第451医院耳鼻咽喉科,西安710054 [2]第四军医大学西京医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉科杂志》1999年第12期542-544,共3页Journal of Clinical Otorhinolaryngology

基　　金：全军中青年人才基金

摘　　要：目的：了解恶性网织细胞增生症（MMH）的病理形态学改变，从免疫表型的研究角度进一步阐明MMH中异型淋巴细胞（ALC）的来源属性，探讨MMH与恶性淋巴瘤的关系。方法：对确诊的39例MMH病理组织切片常规HE染色，光镜下观察病理形态改变；同时行免疫组织化学染色（SP法）。结果：①MMH的病理为凝固性坏死伴混合炎性细胞浸润，具有亲上皮性浸润、围绕血管中心分布和破坏血管等特征。②39例MMH中28例（71．8％）表达T细胞免疫表型，同时表达CD3和CD57的13例（33．3％）。结论：ALC主要是来自异形T细胞的增生和浸润。ALC除表达CD3免疫表型外，还表达CD57的免疫标记。MMH是一种粘膜相关淋巴组织来源的周围T／NK细胞淋巴瘤。Objective: To understand the clinic opatholgic changes of midline malignant histiocytosis(MMH),and to explain the source of atypical lymphoid cells (ALC) of MMH, so as to search after the relationbetween MMH and malignant lymphoma. Method: Histopathologic section of 39 cases of MMH were taken HEstaining and the histopathologic changes were obsered under microscope. The immunohistochemical staining wasalso used to examine the immunophenotype of ALC. Result: ①Pathologic changes of MMH: coaglation necrosisand mixed inflammatory cells infiltration, with epithelial infiltration which distributed around the center of bloodvessel were their characteristics. ②Immunohistochemical staining result: 28 in 39 cases of MMH (71. 8 % ) ex-pressed the immunophenvtype of T-cell;among them 13 (33. 3%) were finded both positive reaction to CD3 andCD57 antigens with ALCs at the same time. Couclusion: According to immunophenotypic studies, most ALCscame from proliferation and infiltration of atypical T cell. ALCs of MMH expressed not only T-cell markers(CD3),but also NK-associated antigen (CD57). MMH was a mucosa related peripheral T/NK cell lymphoma o-riginally.

关 键 词：MMH 恶性 网织细胞增生 病理 免疫表型 

分 类 号：R733.02[医药卫生—肿瘤]